media solution preparation
IRI: https://spec.industrialontologies.org/ontology/construct/MediaSolutionPreparation
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: solution preparation process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › solution preparation process › media solution preparation
Definition
solution preparation process in which a media powder, an input media solution, or individual media components are dissolved or diluted in water or a buffered solution to produce a media solution that satisfies the material input specification of a target process
Explanatory Notes
This process may involve adjusting pH, sterile filtration, or supplementation with additives depending on the application.
Examples
- dissolving CHO cell culture media powder in water for use in a fed-batch bioreactor; diluting a 10× DMEM stock solution with water to prepare a 1× working media solution; preparing Glasgow Minimum Essential Medium (GMEM) by dissolving powdered GMEM in a sodium bicarbonate buffer
Counter-Examples
- thawing pre-made liquid media before use in cell culture; sterilizing a commercially available ready-to-use media without any modification;
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
MediaSolutionProcess(x) → SolutionPreparationProcess(x) ∧
∃y (CultureMedium(y) ∧ hasSpecifiedOutput(x, y) ∧ ∃z (InputSpecification(z) ∧ satisfiesRequirement(y, z)))
Semi-Formal Natural Language Axioms
if x is a ‘media solution process’ then x is a ‘solution preparation process’ that ‘has specified output’ some ‘culture medium’ and ‘satisfies requirement’ some ‘input specification’
Description Logic
constr:MediaSolutionPreparation ⊑ constr:SolutionPreparationProcess
constr:MediaSolutionPreparation ⊑ ∃ constr:hasSpecifiedOutput .(constr:CultureMedium ⊓ ∃ constr:satisfiesRequirement .constr:InputSpecification)
SubClassOf: constr:SolutionPreparationProcess
SubClassOf: constr:hasSpecifiedOutput some (constr:CultureMedium and constr:satisfiesRequirement some constr:InputSpecification)