tangential flow filtration

IRI: https://spec.industrialontologies.org/ontology/construct/TangentialFlowFiltration

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: filtration process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › filtration process › tangential flow filtration

Definition

filtration process in which the liquid travels tangentially across the surface of the membrane or bed filter

Semi-Formal Definition:

every instance of ‘tangential flow filtration process’ is defined as exactly an instance of ‘filtration process’ that ‘has proper occurrent part’ some ‘tangential flow orientation’

Explanatory Notes

TFF can operate in batch mode (Batch TFF) and continuous mode Single-pass TFF)

Examples

Tangential flow filtration is used to purify and concentrate viral vectors by separating them from residual DNA, cell debris, and small fragments; Tangential flow filtration is applied to concentrate monoclonal antibodies before anion exchange chromatography;

Synonyms

• cross-flow filtration

Formal Axioms

First-Order Logic Definition

TangentialFlowFiltrationProcess(x) ↔ FiltrationProcess(x) ∧ ∃y (TangentialFlowOrientation(y) ∧ hasProperOccurrentPart(x, y))

Description Logic

constr:TangentialFlowFiltration ≡ constr:FiltrationProcess ⊓ ∃ bfo:has_proper_occurrent_part .constr:TangentialFlowOrientation

constr:TangentialFlowFiltration ⊑ constr:FiltrationProcess

constr:TangentialFlowFiltration ⊓ constr:DirectFlowFiltration ⊑ ⊥

EquivalentTo: constr:FiltrationProcess and bfo:has_proper_occurrent_part some constr:TangentialFlowOrientation

SubClassOf: constr:FiltrationProcess

constr:TangentialFlowFiltration DisjointWith: constr:DirectFlowFiltration