cell banking
IRI: https://spec.industrialontologies.org/ontology/construct/CellBanking
Defined In: https://spec.industrialontologies.org/ontology/biopharma/ManufacturingExecution/
SubClass Of: storage process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › storage process › cell banking
Definition
storage process of preserving and maintaining cell lines for future use
Explanatory Notes
1) It ensures a reliable, consistent, and well-characterized source of cells, reducing the need for constant cell culture and mitigating risks associated with genetic drift or contamination. 2) Examples of future use include research, drug development, and manufacturing of biopharmaceuticals
Examples
- establishing a master cell bank by freezing aliquots of a cloned HEK293 cell line under GMP conditions; banking the Vero cell line in cryopreservation medium supplemented with DMSO and storing it in vapor-phase liquid nitrogen for future vaccine manufacturing; banking a hybridoma cell line after single-cell cloning and characterization to preserve monoclonal antibody production capability
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
CellBankingProcess(x) → StorageProcess(x) ∧ ∃y (CellLine(y) ∧ hasParticipantAtSomeTime(x, y)) ∧ ∃z (RecipeProcessOperation(z) ∧ prescribedBy(x, z))
Semi-Formal Natural Language Axioms
if x is a ‘cell banking process’ then x is a ‘storage process’ that ‘has participant at some time’ some ‘cell line’ and is ‘prescribed by’ some ‘recipe process operation’ `
Description Logic
constr:CellBanking ⊑ constr:StorageProcess
constr:CellBanking ⊑ ∃ bfo:has_participant_at_some_time .constr:CellLine
constr:CellBanking ⊑ ∃ constr:prescribedBy .constr:RecipeProcessOperation
SubClassOf: constr:StorageProcess
SubClassOf: bfo:has_participant_at_some_time some constr:CellLine
SubClassOf: constr:prescribedBy some constr:RecipeProcessOperation