protein binding capability

IRI: https://spec.industrialontologies.org/ontology/construct/ProteinBindingCapability

Defined In: https://spec.industrialontologies.org/ontology/biopharma/Equipment/

SubClass Of: capability

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:disposition › capability › protein binding capability

Definition

capability of a material entity to selectively and reversibly interact with one or more protein molecules through non-covalent molecular interactions

Examples

• Protein A resin capability to bind IgG molecules; Immobilized capture antibody on an ELISA plate capability to bind specific (target) protein; . FcRn Receptor capability to bind therapeutic IgG

Counter-Examples

• non-specific binding of proteins to surfaces of plastic containers; covalent imobilization of Protein A on agarose resin; non-specific aggregation of proteins; gel filtration resins - while used for protein purification the interaction mechanism is not binding

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs in the ontology to create necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

ProteinBindingCapability(x) → Capability(x) ∧ ∃z(MaterialEntity(z) ∧ capabilityOf(x, z))

Semi-Formal Natural Language Axioms

if x is a ‘protein binding capability’ then x is a ‘capability’ that is the ‘capability of’ some ‘material entity’

Description Logic

constr:ProteinBindingCapability ⊑ constr:Capability

constr:ProteinBindingCapability ⊑ ∃ constr:capabilityOf .bfo:material_entity

SubClassOf: constr:Capability

SubClassOf: constr:capabilityOf some bfo:material_entity