viral removal process
IRI: https://spec.industrialontologies.org/ontology/construct/ViralRemovalProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/ManufacturingExecution/
SubClass Of: viral clearance
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › manufacturing process › viral clearance › viral removal process
Direct subclasses:
Definition
viral clearance during which viral particles are physically separated from the input material based on differences in physical properties such as size or charge
Examples
- anion exchange chromatography operated in flow-through mode to remove retrovirus-like particles from CHO cell harvest;nanofiltration of plasma-derived products to remove non-enveloped viruses; use of tangential flow filtration to separate viral particles from cell lysate during vaccine production
Adapted From
- https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q-5-r1-viral-safety-evaluation-biotechnology-products-derived-cell-lines-human-animal-origin_en.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
ViralRemovalProcess(x) → ViralClearance(x)
Semi-Formal Natural Language Axioms
if x is a ‘viral removal process’ then x is a ‘viral clearance’