chromatography process
IRI: https://spec.industrialontologies.org/ontology/construct/ChromatographyProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/ManufacturingExecution/
SubClass Of: planned process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › chromatography process
Direct subclasses:
Definition
planned process that results in the separation of components in a mixture based on their distribution between two phases, one of which is stationary and the other moves in a definite direction
Explanatory Notes
The phase moving in a definite direction is called a mobile phase and is a fluid
Examples
- In the recombinant human insulin manufacturing process, a Size Exclusion Chromatography (SEC) process is used for the final polishing step using Sephadex G-25 to remove salts and ensure the proper molecular weight distribution of insulin; Industrial plants devoted to the processing of Corn use a continuous simulated moving bed (SMB) chromatography process to separate fructose from glucose
Adapted From
- CHMO:0001000
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
ChromatographyProcess(x) → PlannedProcess(x) ∧ ∃y (MobilePhase(y) ∧ hasParticipantAtSomeTime(x, y)) ∧ ∃z (StationaryPhase(z) ∧ hasParticipantAtSomeTime(x, z)) ∧ ∃w (RecipeProcessOperation(w) ∧ prescribes(w, x))
Semi-Formal Natural Language Axioms
if x is a ‘chromatography process’ then x is a ‘planned process’ that ‘has participant at some time’ some ‘mobile phase’ and ‘has participant at some time’ some ‘stationary phase’
Description Logic
constr:ChromatographyProcess ⊑ constr:PlannedProcess
constr:ChromatographyProcess ⊑ ∃ bfo:has_participant_at_some_time .constr:MobilePhase
constr:ChromatographyProcess ⊑ ∃ bfo:has_participant_at_some_time .constr:StationaryPhase
constr:ChromatographyProcess ⊑ ∃ constr:prescribedBy .constr:RecipeProcessOperation
SubClassOf: constr:PlannedProcess
SubClassOf: bfo:has_participant_at_some_time some constr:MobilePhase
SubClassOf: bfo:has_participant_at_some_time some constr:StationaryPhase
SubClassOf: constr:prescribedBy some constr:RecipeProcessOperation