acidic charge variant population

IRI: https://spec.industrialontologies.org/ontology/construct/AcidicChargeVariantPopulation

Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/

SubClass Of: protein charge variant population

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object aggregate › molecular entity population › protein charge variant population › acidic charge variant population

Definition

protein charge variant population classified by a protein acidic charge variant classifier

Semi-Formal Definition:

every instance of ‘acidic charge variant population’ is defined as exactly an instance of ‘protein charge variant population’ that is ‘classified by’ some ‘protein acidic charge variant classifier’

Examples

• deamidated monoclonal antibody population; sialylated antibody glycoform-enriched population; acidic peak population detected by cation-exchange chromatography; lower-pI protein population detected by capillary isoelectric focusing

Formal Axioms

First-Order Logic Definition

AcidicChargeVariantPopulation(x) ↔ ProteinChargeVariantPopulation(x) ∧ ∃c(ProteinAcidicChargeVariantClassifier(c) ∧ classifiedBy(x, c))

Description Logic

constr:AcidicChargeVariantPopulation ≡ constr:ProteinChargeVariantPopulation ⊓ ∃ constr:classifiedBy .constr:ProteinAcidicChargeVariantClassifier

constr:AcidicChargeVariantPopulation ⊑ constr:ProteinChargeVariantPopulation

EquivalentTo: constr:ProteinChargeVariantPopulation and constr:classifiedBy some constr:ProteinAcidicChargeVariantClassifier

SubClassOf: constr:ProteinChargeVariantPopulation