flowability
IRI: https://spec.industrialontologies.org/ontology/construct/Flowability
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: capability
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:disposition › capability › flowability
Definition
capability of a material entity to move by flow
Explanatory Notes
Flowability is assessed relative to a handling context and conditions (e.g., gravity discharge, pouring, conveying, pumping, geometry such as hoppers/orifices, temperature and humidity, consolidation history). In bioprocessing and pharmaceutical settings, the term is most commonly applied to powders and granular solids and evaluated using operational tests such as angle of repose, flow through an orifice, and indices derived from bulk and tapped density.
Examples
- the flowability of powdered cell culture medium during hopper discharge; the flowability of granular medium during transfer to a mixing vessel; the flowability of an excipient powder during tablet manufacturing; the flowability of chromatography resin slurry during transfer; the flowability of a dry powder after exposure to high humidity
Adapted From
- https://www.usp.org/sites/default/files/usp/document/harmonization/gen-chapter/20230428HSm99885.pdf and https://en.wikipedia.org/wiki/Flowability and https://www.sciencedirect.com/topics/materials-science/flowability
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
Flowability(x) → Capability(x) ∧ ∃m (MaterialEntity(m) ∧ capabilityOf(x, m))
Semi-Formal Natural Language Axioms
if x is a ‘flowability’ then x is a ‘capability’ that is the ‘capability of’ some ‘material entity’
Description Logic
constr:Flowability ⊑ constr:Capability
constr:Flowability ⊑ ∃ constr:capabilityOf .bfo:material_entity
SubClassOf: constr:Capability
SubClassOf: constr:capabilityOf some bfo:material_entity