glycated residue
IRI: https://spec.industrialontologies.org/ontology/construct/GlycatedResidue
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: glycoconjugated residue
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › amino acid residue › modified amino acid residue › glycoconjugated residue › glycated residue
Definition
glycoconjugated residue that is formed by non-enzymatic covalent attachment of a reducing sugar to an amino group of an amino acid residue, producing a Schiff-base or Amadori-type ketosamine adduct
Examples
- Glycated lysine residue in a monoclonal antibody formed by non-enzymatic reaction of the lysine side-chain amino group with glucose; N-terminal glycated residue in a recombinant protein formed by non-enzymatic reaction of the N-terminal amino group with a reducing sugar;
Adapted From
- http://purl.obolibrary.org/obo/MOD_00767
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of chemical bonds, structure and formation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
GlycatedResidue(x) → GlycoconjugatedResidue(x)
Semi-Formal Natural Language Axioms
if x is a ‘glycated residue’ then x is a ‘glycoconjugated residue’