protein basic charge variant classifier
IRI: https://spec.industrialontologies.org/ontology/construct/ProteinBasicChargeVariantClassifier
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: protein charge variant classifier
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › denoter › classifier › charge variant classifier › protein charge variant classifier › protein basic charge variant classifier
Definition
protein charge variant classifier that classifies a molecular entity population composed of proteins or protein fragments as differing from a reference protein form by having a higher isoelectric point or higher net electric charge under the relevant analytical conditions
Explanatory Notes
The term basic is used in the conventional charge-variant sense, typically reflecting higher isoelectric point, higher net electric charge, or corresponding behavior in methods such as ion-exchange chromatography or capillary isoelectric focusing. It does not mean that the classified population acts as an alkalizing (basifying) agent.
Examples
- classifier that classifies a C-terminal lysine-containing monoclonal antibody population as a basic charge variant; a classifier that classifies an amidated protein population as a basic charge variant; a classifier that classifies a basic peak population detected by cation-exchange chromatography; a classifier that classifies a higher-pI protein population detected by capillary isoelectric focusing;
Adapted From
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5392216/ and https://www.chromatographyonline.com/view/charge-variant-profiling-biopharmaceuticals and https://www.agilent.com/cs/library/applications/compendium-chargevariant-advancebio-5994-0034EN-us-agilent.pdf?srsltid=AfmBOorRMu0dQH4wotghCeKwXSMCdNuuNsAEkA06EkLXupvMO6SBKJaN
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
ProteinBasicChargeVariantClassifier(x) → ProteinChargeVariantClassifier(x)
Semi-Formal Natural Language Axioms
if x is a ‘protein basic charge variant classifier’ then x is a ‘protein charge variant classifier’