🟢 Biopharma Material Ontology

Maturity: 🟢 Released

IRI: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

This module contains terms and relations enabling representation of material types and their associated properties. Terms for characterizing material usages in internal operation systems are also included (e.g., consumable, process intermediate, final product…).

Annotations

Contributor

Adlane Rebai, Millipore Sigma
Ana Nikolov, OAGi
Boonserm Kulvatunyou, NIST
Cameron Gibbs, CrownPoint Technologies, LLC
Gabriela Henning, NIST
Jan Kemper, AstraZeneca
Marie-Aude Coutouly, Millipore Sigma
Melissa Weller, CrownPoint Technologies, LLC
Milos Drobnjakovic, OAGi
Stephen J. Granite, CrownPoint Technologies, LLC
Stephen Kahmann, CrownPoint Technologies, LLC

Copyright

Creator

NIIMBL BD-1 Ontology Group

License

http://opensource.org/licenses/MIT

Title

NIIMBL Material Ontology

Classes (148)

Class	Definition
acidifying agent role	pH adjusting agent role of a material entity when it is used, or planned to be used, to lower pH
alkalizing agent role	pH adjusting agent role of a material entity when it is used, or planned to be used, to raise pH
amount of substance	quality of a material entity that is proportional to the number of elementary entities of a particular kind present in that materi…
antifoaming agent	material entity with an antifoaming agent role
antifoaming agent role	role of a material entity when it is used, or planned to be used, to reduce or prevent foam formation in a liquid
bacterium cell	cell that lacks a membrane-bound nucleus and has ribosomes of the bacterial type
basal culture medium	culture medium which has the basal culture medium role
basal culture medium role	role held by a culture medium when it is used or planned to be used either directly in a cell culture process to provide essential…
bioburden	relational quality of a material entity that is the extent to which viable microorganisms are present in or on the surface of the …
bioproduction supporting function	culture medium specialized function that enables the generation of a target biological product by sustaining cellular activity und…
buffer solution	solution consisting of a mixture of a weak acid and its conjugate base or a weak base and its conjugate acid which is resistant to…
buffering agent role	role of a material entity when it is added or planned to be added to a mixture, typically aqueous, to enable or enhance the mixtur…
buffering capability	capability of a solution to resist a change in pH when acid or base is added
buffering function	function of a solution to resist a change in pH when an acid or base is added
bulk density	mass density of a particulate material that is the mass per total bulk volume occupied by the material, where the total bulk volum…
caking propensity	disposition of a particulate material entity to form persistent lumps, agglomerates, or a coherent solid mass
carbon source role	nutrient role held by a material entity that provides carbon used by an organism or cell for biosynthesis, energy generation, or b…
cell	object of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment su…
cell bank	object aggregate consisting of containers whose contents are uniform portions derived from a single pool of cells and that are sto…
cell count	count that is the number of cells that are present as parts of a material entity
cell culture	material entity that has cultured cells and the media in which they are being propagated or stored as parts
cell culture derived impurity role	manufacturing process related impurity role held by a material entity that originates from an acellular material component of a ce…
cell density	number density that is the number of cells per unit size
cell line	cultured cell population that is derived from a primary cell source and that has been propagated through repeated subculture under…
cell line lineage	history of the development of a cell line
cell population	object aggregate which only has cells as its member parts
cell proliferation supporting function	specialized culture medium function that supports cell division and maintenance of cell viability during expansion culture by prov…
cell substrate derived impurity role	manufacturing process related impurity role held by a material entity that originates from cells used in a manufacturing process
cell viability ratio	relative abundance that is the number of viable cells in a cell population relative to the total number of cells in that populatio…
chemical substance material	material entity that is made primarily of one kind of molecular entity, allowing for minor impurities
chemically defined culture medium	serum free culture medium in which each component and its concentration are known and reproducible, and that excludes undefined co…
cloned cell line	cell line that originates from a single ancestral cell
compendial grade classifier	material grade classifier that classifies a material entity as conforming to the requirements stated in an applicable pharmacopeia…
complete culture medium	culture medium which has the complete culture medium role
complete culture medium role	role held by a culture medium when it is used or planned for direct use in a cell culture process to meet the full set of nutritio…
concentration	relational quality of a mixture that is the amount of substance or number or mass or volume of a specified constituent of the mixt…
contaminant role	material impurity role held by a material entity when it is adventitiously introduced during a manufacturing process
cryoprotective agent role	protective agent role of a material entity when it is used, or planned to be used, to protect one or more other material entities …
culture medium	mixed material that is a liquid, semi-solid or solid formulation that provides essential nutrients (such as carbon, nitrogen, vita…
culture medium supplement	material entity that has a culture medium supplement role
culture medium supplement role	material component role held by a material entity when it is added or planned to be added to culture media to enrich or modify the…
culture preservation function	culture medium specialized function that maintains cell viability and structural integrity during storage and transport by providi…
cultured cell	cell that is grown, maintained, or adapted to grow in a controlled artificial environment that supports its survival and prolifera…
cultured cell population	cell population which only has cultured cells as its member parts
dead	viability status of a biological material entity that has irreversibly ceased to maintain the biological processes characteristic …
dead cell count	cell count that is the number of dead cells that are present as parts of a material entity
dead cell density	cell density that is the number of dead cells per unit size
dead cell population	cell population consisting of only dead cells
dissolution role	role held by a material entity that is realized in a dissolution process in which it participates in forming a solution
dissolved oxygen saturation ratio	solution saturation ratio that is the dissolved oxygen concentration in a liquid solution relative to the dissolved oxygen saturat…
downstream derived impurity role	manufacturing process related impurity role held by a material entity that originates from a raw material, production consumable, …
dusting propensity	disposition of a particulate material entity to generate airborne particulate matter during handling or processing
emulsion propensity	disposition of a material entity to form an emulsion
energy substrate role	nutrient role held by a material entity that is metabolized in cellular pathways to generate adenosine triphosphate, reducing equi…
equilibrium saturation concentration	solution saturation concentration of a particular solute at thermodynamic equilibrium
expansion culture medium	specialized culture medium that has a cell proliferation supporting function
extractable and leachable impurity role	material impurity role held by a material entity in virtue of that material entity being present in a target material as a result …
filterability	capability of a fluid to pass through a filtration medium without undue blockage or loss of permeability
flowability	capability of a material entity to move by flow
foamability	capability of a liquid to form foam during a particular process
hygroscopicity	capability of a material entity to attract and hold moisture from the surrounding environment
impurity fraction	fraction of a material entity that is determined by the proportion of material considered an impurity relative to the material ent…
infected host cell	cell that is infected by a virus or another type of microorganism
inoculum role	role held by a material entity containing biological material when it is being added, or is planned to be added, to initiate or es…
intact molecular mass	molecular mass of a molecular entity or molecular entity population considered in its whole, intact form, without fragmentation, c…
intermediate stock solution role	stock solution role held by a solution when the solution is prepared by diluting another stock solution and is used, or planned to…
isoelectric point	electrical quality of a molecular entity that corresponds to the pH of a homogeneous aqueous mixture at which that molecular entit…
manufacturing process related impurity role	material impurity role held by a material entity that is present in a process intermediate material or material product and whose …
mass concentration	concentration that is the mass of a specified constituent of a mixture per unit volume of that mixture
master cell bank	cell bank produced in a single preparation event from a well-characterized cell line or clone, stored under validated cryogenic co…
material differentiation inducer	material entity with a material differentiation inducer role
material differentiation inducer role	role held by a material entity when it is used, or planned to be used to activate signaling pathways that drive cell fate decision…
material functional inducer	material entity with a material functional inducer role
material functional inducer role	role held by a material entity when it is used, or planned to be used, to trigger, enhance, or repress a specified cellular activi…
material grade classifier	classifier that classifies a material entity into an organization- or authority-defined material grade based on the material entit…
material metabolic inducer	material entity with a material metabolic inducer role
material metabolic inducer role	role held by a material entity when it is used, or planned to be used to activate expression of enzymes or pathways involved in th…
material production inducer	material entity with a material production inducer role
material production inducer role	role held by a material entity when it is added, or planned to be added, to a cell culture to trigger the synthesis of a target pr…
miscibility	capability of two or more material entities to form a single homogeneous phase when combined as a mixture
mixed material	material entity composed of at least two material constituents that are distinct in chemical identity or material composition, exc…
moisture content	ratio that is the mass of water contained in a material entity relative to a defined reference mass of that material entity
molar concentration	concentration that is the amount of substance of a specified constituent of a mixture per unit volume of that mixture
molar mass	quality that is the quality of a molecular entity or population of molecular entities, and is either the mass of one mole of that …
molecular carrier role	role of a material entity when it supports the transport, or delivery of one or more molecular entities in a physical, chemical, o…
molecular mass	mass that is either the mass of a molecular entity or an average of the masses of the molecular entities in a molecular entity pop…
mycoplasma cell	bacterium cell that lacks a rigid cell wall and is capable of infecting mammalian cells
nitrogen source role	nutrient role held by a material entity that provides nitrogen for synthesis of amino acids, nucleotides, and other nitrogen-conta…
non-glycosylated molecular mass	molecular mass of a glycoprotein or population of glycoproteins that characterizes the mass contribution of its non-glycan molecul…
nutrient feed	material entity with a nutrient feed role
nutrient feed role	role held by a material entity when it is added, or planned to be added, to a cell culture during cultivation or production to sup…
nutrient role	role held by a material entity that is made available to an organism or cell to support metabolism, growth, maintenance, or biomas…
osmolality	relational quality of a solution that is the amount of osmotically active solute entities in that solution per unit mass of solven…
osmolarity	relational quality of a solution that is the amount of osmotically active solute entities in that solution per unit volume of that…
partial pressure	pressure that is the contribution of a particular gaseous constituent of a gas mixture to the total pressure of that mixture
pH	quality of a material entity that is quantified as the negative decimal logarithm of the relative activity of hydrogen ions in tha…
pH adjusting agent role	role of a material entity when it is used, or planned to be used to adjust pH
pharmaceutical degradation product impurity role	pharmaceutical product related impurity role held by a material entity that differs from the targeted drug substance or drug produ…
pharmaceutical product related impurity role	material impurity role held by a material entity that is related to the targeted drug substance or drug product but is not part of…
portion of water	chemical substance material composed primarily of water molecules, allowing for minor impurities arising from production, handling…
portion of water for injection	portion of water that is classified by a water for injection classifier
precipitation propensity	disposition of a liquid mixed material to form an insoluble solid phase from dissolved constituents
preservation culture medium	specialized culture medium that has a culture preservation function
production culture medium	specialized culture medium that has a bioproduction supporting function
protective agent role	role of a material entity when it is used or planned to be used to protect one or more other material entities from stress or dama…
protein free culture medium	serum free culture medium that does not include any proteins
protein hydrolysate	mixed material produced by partial or extensive hydrolysis of protein-containing material and composed primarily of oligopeptides,…
reconstitutability	capability of a dried or concentrated material entity to form a liquid mixture that satisfies specified usage requirements when co…
relative abundance	ratio that is determined by the magnitude of a specified member or subset of a defined group of material entities relative to the …
relative humidity	saturation ratio of a gas mixture whose magnitude is the partial pressure of water vapor in that gas mixture relative to the satur…
saturated state	material state of a solution in which the dissolved solute concentration stays at the solute’s equilibrium saturation concentratio…
saturation ratio	ratio of a material entity whose magnitude is the magnitude of a quality of that material entity relative to the magnitude at the …
serum	mixed material that is obtained from blood following coagulation and removal of cells and clotting factors
serum containing culture medium	culture medium that contains serum
serum free culture medium	culture medium that contains no serum
shear protective agent role	protective agent role of a material entity when it is used, or planned to be used, to protect one or more other material entities …
solubility capability	capability of a material entity to dissolve in a particular solvent
solute	material entity with a solute role
solute role	dissolution role held by a material entity that is realized in a process where it is dissolved within another substance (the solve…
solution	mixed material composed of one homogeneous phase in which constituent particles are not visible to the naked eye and that does not…
solution saturation concentration	concentration of a dissolved solute in a solution at the solubility limit of that solute under stated conditions
solution saturation ratio	saturation ratio of a solution whose magnitude is the concentration of a dissolved solute in that solution relative to the saturat…
solution saturation state	material state of a solution in which the dissolved solute concentration stays below, at, or above the solute’s equilibrium satura…
solvent	material entity with a solvent role
solvent role	dissolution role held by a material entity that is realized in a process where it dissolves another substance (the solute) to form…
specialized culture medium	culture medium that has a specialized culture medium function
specialized culture medium function	designed function that inheres in a culture medium and is specified to satisfy the culture requirements of a particular cell type,…
spent culture medium state	material state of culture medium that has participated in a cell cultivation process and is characterized by compositional changes…
stock solution role	role held by a solution that is prepared with an accurately known solute concentration so that measured portions can be diluted to…
supersaturated state	solution saturation state in which the dissolved solute concentration stays above the solute’s equilibrium saturation concentratio…
surface tension	quality of a liquid material entity that is the resistance of the liquid surface to an increase in surface area, arising from unba…
surfactant	material entity with a surfactant role
surfactant role	role of a material entity when it is used, or planned to be used, to lower the surface tension of a medium or the interfacial tens…
tapped density	mass density of a particulate material that is the mass per tapped volume occupied by the material after tapping until little or n…
total cell count	cell count that is the number of all cells present as parts of a material entity
total cell density	cell density that is the total number of cells per unit size
unsaturated state	material state of a solution in which the dissolved solute concentration stays below the solute’s equilibrium saturation concentra…
viability status	quality of a biological material entity by virtue of whether that entity is alive and capable of maintaining or recovering relevan…
viable	viability status of a biological material entity that is alive and capable of maintaining or recovering relevant physiological act…
viable cell count	cell count that is the number of viable cells that are present as parts of a material entity
viable cell density	cell density that is the number of viable cells per unit size
viable cell population	cell population consisting of only viable cells
virus	minute infectious agent that has a DNA or RNA genome, lacks independent metabolism, and replicates only through use of a living ho…
virus seed	object aggregate consisting of containers whose contents are portions of a virus preparation derived from a single defined virus s…
water for injection classifier	compendial grade classifier that classifies a portion of water that conforms to the requirements stated in a Water for Injection p…
wettability	capability of a solid material to be wetted by a liquid
working cell bank	cell bank prepared from cells recovered from one or more containers of a master cell bank and stored under validated cryogenic con…
working solution role	role held by a solution when the solution is prepared from a stock solution or intermediate stock solution at the concentration re…