buffering capability
IRI: https://spec.industrialontologies.org/ontology/construct/BufferingCapability
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: capability
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:disposition › capability › buffering capability
Direct subclasses:
Definition
capability of a solution to resist a change in pH when acid or base is added
Explanatory Notes
Buffering capability is realized when a solution resists pH change in the presence of acid or base material. The acid or base material may be externally added, such as during pH adjustment or titration, or may arise within the system, such as acidic species generated during cell culture metabolism, CO₂ dissolution from culture respiration, or basic species formed through process chemistry. Buffering capability should be distinguished from buffering capacity, which characterizes the extent or strength of this capability.
Examples
- the buffering capability of a phosphate buffer during acid addition; the buffering capability of a bicarbonate-buffered cell culture medium under CO₂ control; the buffering capability of a formulation buffer during base addition; the buffering capability of a chromatography buffer during pH adjustment; the buffering capability of a harvest fluid when acidic or basic species are introduced
Adapted From
- https://www.med.unc.edu/pharm/sondeklab/wp-content/uploads/sites/868/2018/10/buffers_calbiochem.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
BufferingCapability(x) → Capability(x) ∧ ∃s (Solution(s) ∧ capabilityOf(x, s))
Semi-Formal Natural Language Axioms
if x is a ‘buffering capability’ then x is a ‘capability’ that is the ‘capability of’ some ‘solution’
Description Logic
constr:BufferingCapability ⊑ constr:Capability
constr:BufferingCapability ⊑ ∃ constr:capabilityOf .constr:Solution
SubClassOf: constr:Capability
SubClassOf: constr:capabilityOf some constr:Solution