biological sequence variant

IRI: https://spec.industrialontologies.org/ontology/construct/BiologicalSequenceVariant

Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/

SubClass Of: organic molecular entity

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › molecular entity › organic molecular entity › biological sequence variant

Definition

DNA or RNA or protein or peptide classified by a biological sequence variant classifier

Semi-Formal Definition:

every instance of ‘biological sequence variant’ is defined as exactly an instance of ‘deoxyribonucleic acid’, ‘ribonucleic acid’, ‘peptide’, or ‘protein’ that is ‘classified by’ some ‘biological sequence variant classifier’

Examples

• recombinant protein molecule with an amino acid substitution detected by peptide mapping; truncated monoclonal antibody heavy-chain molecule detected in a drug substance lot

Formal Axioms

First-Order Logic Definition

BiologicalSequenceVariant(x) ↔ (DeoxyribonucleicAcid(x) ∨ RibonucleicAcid(x) ∨ Peptide(x) ∨ Protein(x)) ∧ ∃r(BiologicalSequenceVariantClassifier(r) ∧ classifiedBy(x, r))

Description Logic

constr:BiologicalSequenceVariant ≡ (constr:DeoxyribonucleicAcid ⊔ constr:Peptide ⊔ constr:Protein ⊔ constr:RibonucleicAcid) ⊓ ∃ constr:classifiedBy .constr:BiologicalSequenceVariantClassifier

constr:BiologicalSequenceVariant ⊑ constr:OrganicMolecularEntity

EquivalentTo: (constr:DeoxyribonucleicAcid or constr:Peptide or constr:Protein or constr:RibonucleicAcid) and constr:classifiedBy some constr:BiologicalSequenceVariantClassifier

SubClassOf: constr:OrganicMolecularEntity