homogeneity

IRI: https://spec.industrialontologies.org/ontology/construct/Homogeneity

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaReferenceOntologyAttributes/

SubClass Of: bfo:quality

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › homogeneity

Direct subclasses:

• compositional homogeneity
• quality homogeneity

Definition

quality of a material entity that is the extent to which a particular constituent of that material entity, or a particular quality of that material entity, is uniformly distributed throughout that material entity

Explanatory Notes

Homogeneity is always relative to what is being evaluated, such as a particular analyte, particle size fraction, moisture content, pH, osmolality, or optical density. When homogeneity concerns a quality, what is evaluated in practice is the uniformity of the values or observable manifestations of that quality across the material. The same quantity of material may be homogeneous with respect to one constituent or quality and heterogeneous with respect to another, because different constituents or qualities can vary differently across the material. For example, a powder blend may be homogeneous in total mass fraction of a salt but heterogeneous in trace element distribution; a reconstituted medium may be homogeneous in bulk pH but heterogeneous in dissolved gas concentration immediately after mixing.

Examples

• Homogeneity of glucose concentration throughout a prepared culture medium lot; Homogeneity of pH throughout a reconstituted buffer preparation; Homogeneity of trace element distribution throughout a powdered cell culture medium blend; Homogeneity of particle size distribution in a dry powder mixture; Homogeneity of osmolality across sublots of a prepared medium batch; Homogeneity of optical density in a well-mixed cell suspension

Adapted From

• https://goldbook.iupac.org/terms/view/H02845

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

Homogeneity(x) → Quality(x) ∧ ∃m (MaterialEntity(m) ∧ qualityOf(x, m))

Semi-Formal Natural Language Axioms

if x is a ‘homogeneity’ then x is a ‘quality’ that is ‘quality of’ some ‘material entity’

Description Logic

constr:Homogeneity ⊑ bfo:quality

constr:Homogeneity ⊑ ∃ constr:qualityOf .bfo:material_entity

SubClassOf: bfo:quality

SubClassOf: constr:qualityOf some bfo:material_entity