volumetric productivity
IRI: https://spec.industrialontologies.org/ontology/construct/VolumetricProductivity
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaParameter/
SubClass Of: manufacturing process productivity
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › bfo:process profile › rate process profile › manufacturing process productivity › volumetric productivity
Definition
manufacturing process productivity whose magnitude is normalized by a specified reference volume of process material
Explanatory Notes
In upstream biopharma manufacturing process volume is typically the culture working volume
Examples
- monoclonal antibody mass produced per liter of culture working volume per day during a CHO fed-batch process; recombinant protein mass produced per liter of microbial fermentation volume per hour; viral vector genome copies produced per liter of culture volume per day; enzyme activity units produced per liter of culture working volume per hour;
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
VolumetricProductivity(x) → ManufacturingProcessProductivity(x)
Semi-Formal Natural Language Axioms
if x is a ‘volumetric productivity’ then x is a ‘manufacturing process productivity’