material functional inducer role

IRI: https://spec.industrialontologies.org/ontology/construct/MaterialFunctionalInducerRole

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:role

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › material functional inducer role

Direct subclasses:

• material differentiation inducer role
• material metabolic inducer role
• material production inducer role

Definition

role held by a material entity when it is used, or planned to be used, to trigger, enhance, or repress a specified cellular activity or pathway in a cell culture, organism, or microbial community beyond baseline nutrient support

Examples

• the material functional inducer role of IPTG in induction of recombinant protein expression in an E. coli lac-based expression system; the material functional inducer role of doxycycline in a tetracycline-inducible mammalian expression system; the material functional inducer role of methanol in induction of AOX1-driven expression in Komagataella phaffii; the material functional inducer role of galactose in induction of a GAL promoter system in yeast; the material functional inducer role of retinoic acid in directing cellular differentiation

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

MaterialFunctionalInducerRole(x) → Role(x) ∧ ∃m (MaterialEntity(m) ∧ roleOf(x, m))

Semi-Formal Natural Language Axioms

if x is a ‘material functional inducer role’ then x is a ‘role’ that is the ‘role of’ some ‘material entity’

Description Logic

constr:MaterialFunctionalInducerRole ⊑ bfo:role

constr:MaterialFunctionalInducerRole ⊑ ∃ constr:roleOf .bfo:material_entity

SubClassOf: bfo:role

SubClassOf: constr:roleOf some bfo:material_entity