vessel volumes per day
IRI: https://spec.industrialontologies.org/ontology/construct/VesselVolumesPerDay
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaParameter/
SubClass Of: normalized flow rate
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › bfo:process profile › rate process profile › flow rate › normalized flow rate › vessel volumes per day
Definition
normalized flow rate whose magnitude is the volume of medium exchanged per day relative to the working volume
Explanatory Notes
VVD is typically intended to represent the total medium exchange normalized by working volume. In some uses, VVD is computed only from the spent-medium outlet flow, while other withdrawals such as sampling, bleed, or additional removal streams are not included. When this narrower accounting is used, the reported VVD can underestimate the true total exchange and can lead to misleading comparisons unless the boundary is made explicit.
Examples
- a perfusion culture operated at 1 VVD, meaning one working volume of medium is exchanged over one day; a 2 L working-volume bioreactor with 2 L of medium exchanged per day, corresponding to 1 VVD; a perfusion process reported as 0.5 VVD when the daily exchanged medium volume is half of the working volume;
Adapted From
- https://documents.thermofisher.com/TFS-Assets/BPD/Reference-Materials/perfusion-terminology-white-paper.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
VesselVolumesPerDay(x) → NormalizedFlowRate(x)
Semi-Formal Natural Language Axioms
if x is a ‘vessel volumes per day’ then x is a ‘normalized flow rate’