filterability
IRI: https://spec.industrialontologies.org/ontology/construct/Filterability
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: capability
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:disposition › capability › filterability
Definition
capability of a fluid to pass through a filtration medium without undue blockage or loss of permeability
Explanatory Notes
1) Filterability is realized in filtration and concerns the tendency of a fluid-solid material to continue passing through a filtration medium rather than rapidly forming deposits that reduce permeability or cause plugging. 2) The bearer can be a fluid material entity containing suspended solids, with slurries and suspensions being common examples. Filterability can vary with the amount and character of suspended solids, properties of the continuous phase, and the filtration medium used. 3) Practical indications of poor filterability include early blockage, marked decline in throughput, rapid pressure increase, or rapid increase in filtration resistance during filtration.
Examples
- the filterability of a clarified harvest feed before sterile filtration; the filterability of a cell culture harvest containing residual cell debris; the filterability of a protein formulation containing aggregates
Adapted From
- https://www.sciencedirect.com/topics/chemistry/filterability and https://www.cytivalifesciences.com/en/us/insights/how-to-run-a-filterability-test-for-bioprocess-development
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
Filterability(x) → Capability(x) ∧ ∃m (MaterialEntity(m) ∧ capabilityOf(x, m) ∧ ∃s (FluidAggregateState(s) ∧ hasQuality(m, s)))
Semi-Formal Natural Language Axioms
if x is a ‘filterability’ then x is a ‘capability’ that is the ‘capability of’ some ‘material entity’ that ‘has quality’ some ‘fluid aggregate state’
Description Logic
constr:Filterability ⊑ constr:Capability
constr:Filterability ⊑ ∃ constr:capabilityOf .(bfo:material_entity ⊓ ∃ constr:hasQuality .constr:FluidAggregateState)
SubClassOf: constr:Capability
SubClassOf: constr:capabilityOf some (bfo:material_entity and constr:hasQuality some constr:FluidAggregateState)