culture medium charging process
IRI: https://spec.industrialontologies.org/ontology/construct/CultureMediumChargingProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: material addition process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › material addition process › culture medium charging process
Definition
material addition process in which culture medium is added to a culture vessel in preparation for cell culture inoculation
Explanatory Notes
A culture medium charging process establishes the culture medium contents that will receive inoculum. The charged medium may be complete culture medium, growth medium, seed medium, expansion medium, production medium, or another culture-medium formulation, depending on the culture process. It should be distinguished from cell culture inoculation, where inoculum is added to establish a cell culture, and from culture feed addition, where culture medium or nutrient feed is added to an already inoculated cell culture during a culture process.
Examples
- charging medium into a production bioreactor before seed culture inoculation; adding recovery medium to a shake flask before thawed cell suspension inoculation; charging fermentation medium into a vessel before microbial inoculum addition.
Adapted From
- https://www.emerson.com/documents/automation/article-electronic-workflow-for-a-bioreactor-deltav-en-56666.pdf and https://www.eppendorf.com/product-media/doc/en/897339/Fermentors-Bioreactors_Publication_Bioprocess_Bioprocessing-basics.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
CultureMediumChargingProcess(x) → MaterialAdditionProcess(x) ∧ ∃a∃c∃ar∃m∃mr∃i(MaterialArtifact(a) ∧ CellCultureHoldingCapability(c) ∧ hasCapability(a,c) ∧ MaterialAdditionTargetRole(ar) ∧ hasParticipantAtSomeTime(x,a) ∧ hasRole(a,ar) ∧ CultureMedium(m) ∧ TransferredMaterialRole(mr) ∧ hasInput(x,m) ∧ hasRole(m,mr) ∧ CellCultureInoculationProcess(i) ∧ precedes(x,i))
Semi-Formal Natural Language Axioms
if x is a ‘culture medium charging process’ then x is a ‘material addition process’ that ‘has participant at some time’ some ‘material artifact’ that ‘has capability’ some ‘cell culture holding capability’ and ‘has role’ some ‘material addition target role’, ‘has input’ some ‘culture medium’ that ‘has role’ some ‘transferred material role’, and ‘precedes’ some ‘cell culture inoculation process’
Description Logic
constr:CultureMediumChargingProcess ⊑ constr:MaterialAdditionProcess
constr:CultureMediumChargingProcess ⊑ ∃ bfo:has_participant_at_some_time .(constr:MaterialArtifact ⊓ ∃ constr:hasCapability .constr:CellCultureHoldingCapability ⊓ ∃ constr:hasRole .constr:MaterialAdditionTargetRole)
constr:CultureMediumChargingProcess ⊑ ∃ bfo:precedes .constr:CellCultureInoculationProcess
constr:CultureMediumChargingProcess ⊑ ∃ constr:hasInput .(constr:CultureMedium ⊓ ∃ constr:hasRole .constr:TransferredMaterialRole)
SubClassOf: constr:MaterialAdditionProcess
SubClassOf: bfo:has_participant_at_some_time some (constr:MaterialArtifact and constr:hasCapability some constr:CellCultureHoldingCapability and constr:hasRole some constr:MaterialAdditionTargetRole)
SubClassOf: bfo:precedes some constr:CellCultureInoculationProcess
SubClassOf: constr:hasInput some (constr:CultureMedium and constr:hasRole some constr:TransferredMaterialRole)