online monitoring process

IRI: https://spec.industrialontologies.org/ontology/construct/OnlineMonitoringProcess

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMonitoringAndControl/

SubClass Of: monitoring process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › monitoring process › online monitoring process

Definition

monitoring process consisting of one or more measurement processes that are preceded by or temporally overlapped by a material sampling process, in which material representing the entity of interest is collected from a process stream or in-process material and measured using analytical equipment connected to the process equipment

Explanatory Notes

1) Depending on the analytical arrangement, the sampled material may be returned, discarded, consumed, diluted, or mixed with reagents. 2) On-line monitoring differs from in-line monitoring because in-line monitoring does not involve a material sampling process before measurement. 3) On-line monitoring differs from at-line and off-line monitoring because material transfer and measurement occur through analytical equipment connected to equipment used in the associated planned process, rather than by bringing the sample to separately located analytical equipment. 4) Electronic transmission of measurement results does not by itself make a monitoring process on-line. The classification concerns the connected material-sampling and analytical arrangement.

Examples

• monitoring glucose, lactate, and ammonium by automatically diverting a bioreactor sidestream through a connected Raman flow cell and then returning or discarding the analyzed material; monitoring protein concentration during chromatography by diverting eluate through a connected UV flow cell

Adapted From

• https://www.hamiltoncompany.com/knowledge-base/article/bioprocess-monitoring-and-control?srsltid=AfmBOopxhhPv6WbMS7X9JSrLqEcmh6O53_Ap2y2HugM4ZBwyhECSjEa-

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

OnlineMonitoringProcess(x) → MonitoringProcess(x) ∧ ∃s∃m∃a (MaterialSamplingProcess(s) ∧ MeasurementProcess(m) ∧ MaterialSample(a) ∧ hasOccurrentPart(x, s) ∧ hasOccurrentPart(x, m) ∧ hasSpecifiedOutput(s, a) ∧ hasInput(m, a) ∧ (precedes(s, m) ∨ temporallyOverlaps(s, m)))

Semi-Formal Natural Language Axioms

if x is an ‘online monitoring process’ then x is a ‘monitoring process’ that ‘has occurrent part’ some ‘material sampling process’ s and some ‘measurement process’ m, and s ‘has specified output’ some ‘material sample’ a, m ‘has input’ a, and s either ‘precedes’ or ‘temporally overlaps’ m

Description Logic

constr:OnlineMonitoringProcess ⊑ constr:MonitoringProcess

constr:OnlineMonitoringProcess ⊑ ∃ bfo:has_occurrent_part .(constr:MaterialSamplingProcess ⊓ (∃ bfo:precedes .(constr:MeasurementProcess ⊓ ∃ constr:hasInput .constr:MaterialSample) ⊔ ∃ constr:temporallyOverlaps .(constr:MeasurementProcess ⊓ ∃ constr:hasInput .constr:MaterialSample)))

constr:OnlineMonitoringProcess ⊓ constr:AtlineMonitoringProcess ⊑ ⊥

constr:OnlineMonitoringProcess ⊓ constr:InlineMonitoringProcess ⊑ ⊥

constr:OnlineMonitoringProcess ⊓ constr:OfflineMonitoringProcess ⊑ ⊥

SubClassOf: constr:MonitoringProcess

SubClassOf: bfo:has_occurrent_part some (constr:MaterialSamplingProcess and (bfo:precedes some (constr:MeasurementProcess and constr:hasInput some constr:MaterialSample) or constr:temporallyOverlaps some (constr:MeasurementProcess and constr:hasInput some constr:MaterialSample)))

constr:OnlineMonitoringProcess DisjointWith: (constr:AtlineMonitoringProcess, constr:InlineMonitoringProcess, constr:OfflineMonitoringProcess)