enzyme inhibitor role
IRI: https://spec.industrialontologies.org/ontology/construct/EnzymeInhibitorRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: enzyme regulator role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › molecular activity regulator role › enzyme regulator role › enzyme inhibitor role
Definition
role held by a molecular entity that is realized in an enzyme catalyzed reaction through decreasing or preventing the catalytic activity of the enzyme
Examples
- Inhibitor role held by aprotinin when added to cell culture media to inhibit serine proteases and prevent product degradation; Role held by sodium fluoride when inhibiting enolase in glycolytic pathways; Inhibitor role held by cyanide when binding to cytochrome oxidase and blocking electron transport
Adapted From
- https://www.ebi.ac.uk/chebi/CHEBI:23924
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of molecular activity modulation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
EnzymeInhibitorRole(x) → EnzymeRegulatorRole(x)
Semi-Formal Natural Language Axioms
if x is an ‘enzyme inhibitor role’ then x is an ‘enzyme regulator role’