particle size distribution

IRI: https://spec.industrialontologies.org/ontology/construct/ParticleSizeDistribution

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaReferenceOntologyAttributes/

SubClass Of: bfo:quality

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › particle size distribution

Definition

quality of a particle population that is the distribution of physical sizes of the particles in that population

Explanatory Notes

Particle size distribution describes a population-level morphological quality, not the size of a single particle. It may be represented using size-frequency or cumulative distribution data, such as the relative fraction of particles within defined size intervals or percentile-based descriptors such as D10, D50, and D90. Summary statistics such as mean particle size may be reported together with particle size distribution data, but a mean value alone does not fully characterize the distribution.

Examples

• Particle size distribution of a powdered cell culture media lot reported as D10, D50, and D90 values from laser diffraction; Particle size distribution of a granulated media formulation reported as the percentage of particles within predefined size intervals; Particle size distribution of an excipient powder reported as retained mass fraction on a series of sieves; Particle size distribution of an excipient powder used in formulation, assessed to support flowability, mixing performance, and dose uniformity;

Adapted From

• https://www.sciencedirect.com/topics/chemistry/particle-size-distribution

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

ParticleSizeDistribution(x) → Quality(x) ∧ ∃m (MaterialEntity(m) ∧ qualityOf(x, m) ∧ ∃f (ParticulateForm(f) ∧ hasQuality(m, f)))

Semi-Formal Natural Language Axioms

if x is a ‘particle size distribution’ then x is a ‘quality’ that is the ‘quality of’ some ‘material entity’ that ‘has quality’ some ‘particulate form’

Description Logic

constr:ParticleSizeDistribution ⊑ bfo:quality

constr:ParticleSizeDistribution ⊑ ∃ constr:qualityOf .(bfo:material_entity ⊓ ∃ constr:hasQuality .constr:ParticulateForm)

SubClassOf: bfo:quality

SubClassOf: constr:qualityOf some (bfo:material_entity and constr:hasQuality some constr:ParticulateForm)