continuous process operating mode
IRI: https://spec.industrialontologies.org/ontology/construct/ContinuousProcessOperatingMode
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: planned process operating mode
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › process characteristic › planned process operating mode › continuous process operating mode
Direct subclasses:
Definition
process operating mode that characterizes a planned process in which input material is introduced into the process while output material is concomitantly removed from the same process over the whole operating interval
Examples
- continuous process operating mode of perfusion cell culture with fresh medium introduction and concomitant harvest removal through a cell retention device; continuous process operating mode of simulated moving-bed chromatography with feed introduction and concomitant product-stream removal; continuous process operating mode of single-pass TFF with feed and buffer introduction and concomitant product containing retentate removal; continuous process operating mode of crystallization with solute feed introduction and concomitant product slurry withdrawal; Continuous process operating mode of a hydrodealkylation (HDA) process where toluene reacts with hydrogen gas at high temperature (500–660 °C) and pressure (20–60 bar) to produce benzene and methane and diphenyl as a side-product; Continuous process operating mode of a Haber-Bosch process for the synthesis of ammonia from nitrogen and hydrogen gases reacting over an iron-based catalyst at high pressure (150–250 atm) and temperature (400°C–500°C)
Adapted From
- https://www.ema.europa.eu/en/documents/scientific-guideline/ich-guideline-q13-continuous-manufacturing-drug-substances-and-drug-products-step-5_en.pdf and https://gmpua.com/Process/ContinuousManufacturing/ContinuousManufacturing.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
ContinuousProcessOperatingMode(x) → PlannedProcessOperatingMode(x) ∧ ∃p∃a∃r∃m (PlannedProcess(p) ∧ processCharacteristicOf(x,p) ∧ MaterialAdditionProcess(a) ∧ MaterialRemovalProcess(r) ∧ MaterialEntity(m) ∧ hasOccurrentPart(p,a) ∧ hasOccurrentPart(p,r) ∧ (occursSimultaneouslyWith(a,r) ∨ temporallyOverlaps(a,r) ∨ isTemporallyOverlappedBy(a,r)) ∧ hasSpecifiedOutput(r,m) ∧ isOutputOf(m,p))
Semi-Formal Natural Language Axioms
if x is a ‘continuous process operating mode’ then x is a ‘planned process operating mode’ that is the ‘process characteristic of’ some ‘planned process’ p that ‘has occurrent part’ some ‘material addition process’ a and some ‘material removal process’ r, where a either ‘occurs simultaneously with’, ‘temporally overlaps’, or ‘is temporally overlapped by’ r, and r ‘has specified output’ some ‘material entity’ that ‘is output of’ p
Description Logic
constr:ContinuousProcessOperatingMode ⊑ constr:PlannedProcessOperatingMode
constr:ContinuousProcessOperatingMode ⊑ ∃ constr:processCharacteristicOf .(constr:PlannedProcess ⊓ ∃ bfo:has_occurrent_part .(constr:MaterialAdditionProcess ⊓ (∃ constr:isTemporallyOverlappedBy .constr:MaterialRemovalProcess ⊔ ∃ constr:occursSimultaneouslyWith .constr:MaterialRemovalProcess ⊔ ∃ constr:temporallyOverlaps .constr:MaterialRemovalProcess)) ⊓ ∃ bfo:has_occurrent_part .(constr:MaterialRemovalProcess ⊓ ∃ constr:hasSpecifiedOutput .(bfo:material_entity ⊓ ∃ constr:isOutputOf .constr:PlannedProcess) ⊓ ∃ constr:occursSimultaneouslyWith .constr:MaterialAdditionProcess))
SubClassOf: constr:PlannedProcessOperatingMode
SubClassOf: constr:processCharacteristicOf some (constr:PlannedProcess and bfo:has_occurrent_part some (constr:MaterialAdditionProcess and (constr:isTemporallyOverlappedBy some constr:MaterialRemovalProcess or constr:occursSimultaneouslyWith some constr:MaterialRemovalProcess or constr:temporallyOverlaps some constr:MaterialRemovalProcess)) and bfo:has_occurrent_part some (constr:MaterialRemovalProcess and constr:hasSpecifiedOutput some (bfo:material_entity and constr:isOutputOf some constr:PlannedProcess) and constr:occursSimultaneouslyWith some constr:MaterialAdditionProcess))