spinner flask
IRI: https://spec.industrialontologies.org/ontology/construct/SpinnerFlask
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaEquipment/
SubClass Of: flask
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object › material artifact › container › flask › spinner flask
Definition
flask designed for cultivating cells in suspension that has as part a component with a mixing function to keep the culture uniformly agitated
Semi-Formal Definition:
every instance of ‘spinner flask’ is defined as exactly an instance of ‘flask’ that ‘has component part at all times’ some ‘material component’ that ‘has function’ some ‘mixing function’, and x ‘has function’ some ‘suspension cell culture holding function’
Explanatory Notes
The mixing component is typically a magnetic stir bar, paddle, or impeller built into the vessel and externally driven to keep cells and medium evenly agitated. This prevents cell settling and improves oxygen and nutrient distribution. Spinner flasks are commonly used for small-scale suspension cultures (e.g., hybridomas, CHO cells) prior to scale-up into bioreactors.
Examples
- A 250 mL glass spinner flask with a magnetic stirring bar
Counter-Examples
- T-flask for adherent cell culture, which lacks any internal component with a mixing function
Adapted From
- https://www.sciencedirect.com/topics/engineering/spinner-flask
Formal Axioms
First-Order Logic Definition
SpinnerFlask(x) ↔ Flask(x) ∧ ∃c (MaterialComponent(c) ∧ hasComponentPartAtAllTimes(x, c) ∧ ∃a (MixingFunction(a) ∧ hasFunction(c, a))) ∧ ∃h (SuspensionCellCultureHoldingFunction(h) ∧ hasFunction(x, h))
Description Logic
constr:SpinnerFlask ≡ constr:Flask ⊓ ∃ constr:hasComponentPartAtAllTimes .(constr:MaterialComponent ⊓ ∃ constr:hasFunction .constr:MixingFunction) ⊓ ∃ constr:hasFunction .constr:SuspensionCellCultureHoldingFunction
EquivalentTo: constr:Flask and constr:hasComponentPartAtAllTimes some (constr:MaterialComponent and constr:hasFunction some constr:MixingFunction) and constr:hasFunction some constr:SuspensionCellCultureHoldingFunction
SubClassOf: constr:Flask
constr:SpinnerFlask DisjointWith: constr:TFlask