culture feed addition process

IRI: https://spec.industrialontologies.org/ontology/construct/CultureFeedAdditionProcess

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: material addition process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › material addition process › culture feed addition process

Definition

material addition process in which a nutrient feed is added to a cell culture during a culture process

Explanatory Notes

A culture feed addition process occurs after a cell culture has been established by inoculation. It should be distinguished from initial medium charging before inoculation and from inoculation itself.

Examples

• addition of carbohydrate and amino acid feed to a CHO fed-batch culture; bolus addition of nutrient mix to maintain viable cell density during CHO production; controlled exponential glucose feeding in an E. coli high-cell-density culture; perfusion feed supplying fresh medium to a CHO bioreactor

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

CultureFeedAdditionProcess(x) → MaterialAdditionProcess(x) ∧ ∃m ∃r ∃c ∃t∃p(NutrientFeed(m) ∧ TransferredMaterialRole(r) ∧ hasInput(x, m) ∧ hasRole(m, r) ∧ CellCulture(c) ∧ MaterialAdditionTargetRole(t) ∧ hasParticipantAtSomeTime(x, c) ∧ hasRole(c, t) ∧ PlannedProcess(p) ∧ occursDuring(x, p) ∧ hasParticipantAtSomeTime(p, c))

Semi-Formal Natural Language Axioms

if x is a ‘culture feed addition process’ then x is a ‘material addition process’ that ‘has input’ some ‘nutrient feed’ that ‘has role’ some ‘transferred material role’, ‘has participant at some time’ some ‘cell culture’ that ‘has role’ some ‘material addition target role’, and ‘occurs during’ some ‘planned process’ that ‘has participant at some time’ that same ‘cell culture’

Description Logic

constr:CultureFeedAdditionProcess ⊑ constr:MaterialAdditionProcess

constr:CultureFeedAdditionProcess ⊑ ∃ bfo:has_participant_at_some_time .(constr:CellCulture ⊓ ∃ constr:hasRole .constr:MaterialAdditionTargetRole)

constr:CultureFeedAdditionProcess ⊑ ∃ constr:hasInput .(constr:NutrientFeed ⊓ ∃ constr:hasRole .constr:TransferredMaterialRole)

constr:CultureFeedAdditionProcess ⊑ ∃ constr:occursDuring .(constr:PlannedProcess ⊓ ∃ bfo:has_participant_at_some_time .constr:CellCulture)

SubClassOf: constr:MaterialAdditionProcess

SubClassOf: bfo:has_participant_at_some_time some (constr:CellCulture and constr:hasRole some constr:MaterialAdditionTargetRole)

SubClassOf: constr:hasInput some (constr:NutrientFeed and constr:hasRole some constr:TransferredMaterialRole)

SubClassOf: constr:occursDuring some (constr:PlannedProcess and bfo:has_participant_at_some_time some constr:CellCulture)