modified amino acid residue
IRI: https://spec.industrialontologies.org/ontology/construct/ModifiedAminoAcidResidue
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: amino acid residue
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › amino acid residue › modified amino acid residue
Direct subclasses:
Definition
amino acid residue that has undergone covalent modification of side-chain or backbone atoms while remaining part of an intact peptide or protein
Explanatory Notes
This class includes amino acid residues that have undergone a covalent change such as oxidation, reduction, alkylation, acylation, or other modification to their side-chain or backbone atoms while remaining part of an intact peptide or protein. The class does not include moieties that result from cleavage of the peptide backbone or from replacement of the original amino acid at that position
Examples
- Oxidized methionine residue in a monoclonal antibody; Deamidated asparagine residue in a protein; Phosphorylated serine residue in a peptide; Glycated lysine residue in a protein; Alkylated cysteine residue in a peptide.
Adapted From
- http://purl.obolibrary.org/obo/PR_000025513
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of chemical bonds, structure and formation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
ModifiedAminoAcidResidue(x) → AminoAcidResidue(x)
Semi-Formal Natural Language Axioms
if x is a ‘modified amino acid residue’ then x is an ‘amino acid residue’