control point
IRI: https://spec.industrialontologies.org/ontology/construct/ControlPoint
Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/
SubClass Of: design point
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › design point › control point
Definition
design point where the factors are set at levels corresponding to a predefined baseline or reference condition
Explanatory Notes
A control point is a planned condition included in an experimental design to give the experiment a clear point of comparison. In many cases, this is the current or standard process condition, such as an existing platform recipe or standard process setpoints (baseline). In other cases, it may be another deliberately selected condition that is useful for interpreting the experimental results (reference). A control point is not defined by where it lies in the design region. This distinguishes it from a center point, which is defined by the middle levels of the factors. A control point may also be a center point, but only when the selected comparison condition happens to be located at the middle factor levels. Its main purpose is to help interpret how the tested design points differ from a known or selected comparison condition.
Examples
- In a cell-culture design of experiments evaluating alternative feed formulations, the design point specifying the existing platform feed formulation under the standard process settings is included as a control point; it represents the current baseline condition used to compare the new feed formulations and need not be located at the center of the factor ranges.
Adapted From
- https://www.itl.nist.gov/div898/handbook/index.htm
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
ControlPoint(x) → DesignPoint(x)
Semi-Formal Natural Language Axioms
if x is a ‘control point’ then x is a ‘design point’
Description Logic
SubClassOf: constr:DesignPoint