pH adjustment addition process
IRI: https://spec.industrialontologies.org/ontology/construct/PHAdjustmentAdditionProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: material addition process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › material addition process › pH adjustment addition process
Definition
material addition process in which an acidifying or alkalizing material is introduced into a defined recipient to modify pH
Examples
- Controlled dosing of sodium hydroxide (NaOH) into a mammalian cell culture bioreactor during production scale to neutralize acidity from lactate accumulation.
Counter-Examples
- Addition of nutrient feeds (e.g., glucose, amino acids) might indirectly affect pH, but their purpose is metabolic, not direct pH control.
Adapted From
- https://www.sciencedirect.com/science/article/pii/S1871678424005533 and https://pmc.ncbi.nlm.nih.gov/articles/PMC10818583/
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
PHAdjustmentAdditionProcess(x) → MaterialAdditionProcess(x) ∧ ∃m ∃r ∃a (MaterialEntity(m) ∧ TransferredMaterialRole(r) ∧ hasInput(x, m) ∧ hasRole(m, r) ∧ ((AcidifyingAgentRole(a) ∨ AlkalizingAgentRole(a)) ∧ hasRole(m, a)))
Semi-Formal Natural Language Axioms
if x is a ‘pH adjustment addition process’ then x is a ‘material addition process’ that ‘has input’ some ‘material entity’ that ‘has role’ some ‘transferred material role’ and ‘has role’ some ‘acidifying agent role’ or some ‘alkalizing agent role’
Description Logic
constr:PHAdjustmentAdditionProcess ⊑ constr:MaterialAdditionProcess
constr:PHAdjustmentAdditionProcess ⊑ ∃ constr:hasInput .(bfo:material_entity ⊓ ∃ constr:hasRole .constr:TransferredMaterialRole ⊓ ∃ constr:hasRole .(constr:AcidifyingAgentRole ⊔ constr:AlkalizingAgentRole))
SubClassOf: constr:MaterialAdditionProcess
SubClassOf: constr:hasInput some (bfo:material_entity and constr:hasRole some constr:TransferredMaterialRole and constr:hasRole some (constr:AcidifyingAgentRole or constr:AlkalizingAgentRole))