size variant classifier
IRI: https://spec.industrialontologies.org/ontology/construct/SizeVariantClassifier
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: classifier
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › denoter › classifier › size variant classifier
Direct subclasses:
Definition
classifier that classifies a population of material entities according to size-related analytical properties relative to a reference material entity
Explanatory Notes
A size variant classifier is a broad parent for classifiers that group material entities by size-related analytical properties. It is intended to support different material domains, including molecular products and particle-based products. More specific subclasses should be used when the size-related terminology, analytical methods, or reference comparisons are domain-specific, such as protein size variants, molecular size variants, aggregate variants, fragment variants, or lipid nanoparticle particle-size variants. The reference material entity is the material entity prescribed by the relevant design specification as the basis for comparison.
Examples
- a classifier that classifies a group of monoclonal antibody molecules detected as a high molecular weight fraction by size-exclusion chromatography as a size variant relative to a reference monoclonal antibody; a classifier that classifies a group of recombinant protein fragments detected as a low molecular weight fraction by capillary electrophoresis as a size variant relative to a reference recombinant protein; a classifier that classifies a group of antibody-drug conjugate molecules according to size-related analytical properties under a product-specific size variant method;
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
SizeVariantClassifier(x) → Classifier(x) ∧ ∃s (DesignSpecification(s) ∧ isAbout(x, s) ∧ ∃r (MaterialEntity(r) ∧ prescribes(s, r))) ∧ ∃g (ObjectAggregate(g) ∧ classifies(x, g))
Semi-Formal Natural Language Axioms
if x is a ‘size variant classifier’ then x is a ‘classifier’ that ‘is about’ some ‘design specification’ that ‘prescribes’ some ‘material entity’, and x ‘classifies’ some ‘object aggregate’
Description Logic
constr:SizeVariantClassifier ⊑ constr:Classifier
constr:SizeVariantClassifier ⊑ ∃ constr:classifies .bfo:object_aggregate
constr:SizeVariantClassifier ⊑ ∃ constr:isAbout .(constr:DesignSpecification ⊓ ∃ constr:prescribes .bfo:material_entity)
SubClassOf: constr:Classifier
SubClassOf: constr:classifies some bfo:object_aggregate
SubClassOf: constr:isAbout some (constr:DesignSpecification and constr:prescribes some bfo:material_entity)