isoelectric point

IRI: https://spec.industrialontologies.org/ontology/construct/IsoelectricPoint

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: electrical quality

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › electrical quality › isoelectric point

Definition

electrical quality of a molecular entity that corresponds to the pH of a homogeneous aqueous mixture at which that molecular entity has zero net electric charge and does not migrate in an electric field

Examples

• a monoclonal antibody with pI 8.6; an enzyme with pI 5.2; a peptide with pI 9.1; an amino acid with pI 6.0; a protein variant whose pI shifts from 7.8 to 8.1 after sequence modification; a charged protein impurity with pI 4.9

Adapted From

• http://purl.obolibrary.org/obo/NCIT_C54157

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

IsoelectricPoint(x) → ElectricalQuality(x) ∧ ∃m (MolecularEntity(m) ∧ qualityOf(x, m))

Semi-Formal Natural Language Axioms

if x is an ‘isoelectric point’ then x is an ‘electrical quality’ that is the ‘quality of’ some ‘molecular entity’

Description Logic

constr:IsoelectricPoint ⊑ constr:ElectricalQuality

constr:IsoelectricPoint ⊑ ∃ constr:qualityOf .constr:MolecularEntity

SubClassOf: constr:ElectricalQuality

SubClassOf: constr:qualityOf some constr:MolecularEntity