buffer solution
IRI: https://spec.industrialontologies.org/ontology/construct/BufferSolution
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: solution
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › mixed material › solution › buffer solution
Definition
solution consisting of a mixture of a weak acid and its conjugate base or a weak base and its conjugate acid which is resistant to pH changes upon addition of an acidic or basic component
Semi-Formal Definition:
every instance of ‘buffer solution’ is defined as exactly an instance of ‘solution’ that ‘has function’ some ‘buffering function’
Examples
- phosphate buffer used during protein purification; acetate buffer used during chromatography; citrate buffer used in formulation development; Tris buffer used during biochemical processing; HEPES-buffered culture medium; bicarbonate-buffered culture medium under CO₂ control
Adapted From
- http://purl.obolibrary.org/obo/NCIT_C70815 and https://www.fda.gov/files/drugs/published/pH-Adjuster-Webinar-Slides.pdf
Formal Axioms
First-Order Logic Definition
BufferSolution(x) ↔ Solution(x) ∧ ∃f (BufferingFunction(f) ∧ hasFunction(x, f))
Description Logic
EquivalentTo: constr:Solution and constr:hasFunction some constr:BufferingFunction
SubClassOf: constr:Solution