cryoprotective agent role
IRI: https://spec.industrialontologies.org/ontology/construct/CryoprotectiveAgentRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: protective agent role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › protective agent role › cryoprotective agent role
Definition
protective agent role of a material entity when it is used, or planned to be used, to protect one or more other material entities from damage during cooling, freezing, frozen storage, or thawing
Explanatory Notes
1) This role is realized through physicochemical effects that help preserve molecular, cellular, or material integrity during cooling, freezing, frozen storage, or thawing. These effects may include reducing formation of large ice crystals, stabilizing hydration state, maintaining osmotic balance, and limiting cold-induced or thaw-induced damage. 2) The protected material may be present in a solution, suspension, culture medium, formulation, cryopreservation medium, or other relevant material context. 3) The role may be borne by a single substance or by a formulated mixture, such as a cryoprotective solution
Examples
- role held by Dimethyl sulfoxide (DMSO) added to freezing medium for cell preservation; role held by a glycerol solution protecting microbial cultures during storage at low temperatures
Adapted From
- http://id.nlm.nih.gov/mesh/D003451 and http://purl.obolibrary.org/obo/NCIT_C53306
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
CryoprotectiveAgentRole(x) → ProtectiveAgentRole(x)
Semi-Formal Natural Language Axioms
if x is a ‘cryoprotective agent role’ then x is a ‘protective agent role’