virus seed

IRI: https://spec.industrialontologies.org/ontology/construct/VirusSeed

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:object aggregate

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object aggregate › virus seed

Definition

object aggregate consisting of containers whose contents are portions of a virus preparation derived from a single defined virus source and maintained as a referenceable lot

Examples

• master virus seed stock for production of an adenovirus-based vaccine, consisting of multiple frozen portions derived from a single characterized virus preparation; working virus seed vials prepared from the master virus seed and used to initiate manufacturing of viral vectors for gene therapy production

Adapted From

• https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q5ar2-guideline-viral-safety-evaluation-biotechnology-products-derived-cell-lines-human-or-animal-origin-step-5_en.pdf and https://extranet.who.int/prequal/glossary-acronyms/s#:~:text=A%20master%20seed%20lot%20

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

VirusSeed(x) → ObjectAggregate(x)

Semi-Formal Natural Language Axioms

if x is a ‘virus seed’ then x is an ‘object aggregate’

Description Logic

constr:VirusSeed ⊑ bfo:object_aggregate

SubClassOf: bfo:object_aggregate