complex sialylated N-glycan moiety
IRI: https://spec.industrialontologies.org/ontology/construct/ComplexSialylatedNGlycanMoiety
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: biantennary complex N-glycan moiety
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › N-glycan moiety › core pentasaccharide N-glycan moiety › biantennary complex N-glycan moiety › complex sialylated N-glycan moiety
Direct subclasses:
Definition
biantennary complex N-glycan moiety that has as part one or more sialic acid residues
Semi-Formal Definition:
every instance of ‘complex sialylated N-glycan moiety’ is defined as exactly an instance of ‘biantennary complex N-glycan moiety’ that ‘has proper continuant part at all times’ some ‘sialic acid residue’
Examples
- Sialylated biantennary complex N-glycan moiety with one terminal sialic acid residue; Disialylated biantennary complex N-glycan moiety with two terminal sialic acid residues;
Adapted From
- https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-development-production-characterisation-and-specification-monoclonal-antibodies-and-related-products-revision-1_en.pdf and http://www.jbiomed.com/v04p0035.htm and https://pmc.ncbi.nlm.nih.gov/articles/PMC4634315/
Formal Axioms
First-Order Logic Definition
ComplexSialylatedNGlycanMoiety(x) ↔ BiantennaryComplexNGlycanMoiety(x) ∧ ∃y (hasProperContinuantPartAtAllTimes(x, y) ∧ SialicAcidResidue(y))
Description Logic
constr:ComplexSialylatedNGlycanMoiety ≡ constr:BiantennaryComplexNGlycanMoiety ⊓ ∃ bfo:has_proper_continuant_part_at_all_times .constr:SialicAcidResidue
constr:ComplexSialylatedNGlycanMoiety ⊑ constr:BiantennaryComplexNGlycanMoiety
constr:ComplexSialylatedNGlycanMoiety ⊓ constr:ComplexASialylatedNGlycanMoiety ⊑ ⊥
EquivalentTo: constr:BiantennaryComplexNGlycanMoiety and bfo:has_proper_continuant_part_at_all_times some constr:SialicAcidResidue
SubClassOf: constr:BiantennaryComplexNGlycanMoiety
constr:ComplexSialylatedNGlycanMoiety DisjointWith: constr:ComplexASialylatedNGlycanMoiety