complex afucosylated N-glycan moiety
IRI: https://spec.industrialontologies.org/ontology/construct/ComplexAFucosylatedNGlycanMoiety
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: biantennary complex N-glycan moiety
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › N-glycan moiety › core pentasaccharide N-glycan moiety › biantennary complex N-glycan moiety › complex afucosylated N-glycan moiety
Definition
biantennary complex N-glycan moiety that has no fucose residues as parts
Semi-Formal Definition:
every instance of ‘complex afucosylated N-glycan moiety’ is defined as exactly an instance of ‘biantennary complex N-glycan moiety’ that ‘has proper continuant part at all times’ no ‘fucose residue’
Examples
- G0 biantennary complex N-glycan moiety with no fucose residue; G1 biantennary complex N-glycan moiety with no fucose residue; G2 biantennary complex N-glycan moiety with no fucose residue.
Adapted From
- https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-development-production-characterisation-and-specification-monoclonal-antibodies-and-related-products-revision-1_en.pdf and http://www.jbiomed.com/v04p0035.htm and https://pmc.ncbi.nlm.nih.gov/articles/PMC4634315/
Formal Axioms
First-Order Logic Definition
ComplexAFucosylatedNGlycanMoiety(x) ↔ BiantennaryComplexNGlycanMoiety(x) ∧ ¬∃y (hasProperContinuantPartAtAllTimes(x, y) ∧ FucoseResidue(y))
Description Logic
constr:ComplexAFucosylatedNGlycanMoiety ≡ constr:BiantennaryComplexNGlycanMoiety ⊓ ¬ ∃ bfo:has_proper_continuant_part_at_all_times .constr:FucoseResidue
constr:ComplexAFucosylatedNGlycanMoiety ⊑ constr:BiantennaryComplexNGlycanMoiety
constr:ComplexAFucosylatedNGlycanMoiety ⊓ constr:ComplexFucosylatedNGlycanMoiety ⊑ ⊥
EquivalentTo: constr:BiantennaryComplexNGlycanMoiety and not bfo:has_proper_continuant_part_at_all_times some constr:FucoseResidue
SubClassOf: constr:BiantennaryComplexNGlycanMoiety
constr:ComplexAFucosylatedNGlycanMoiety DisjointWith: constr:ComplexFucosylatedNGlycanMoiety