inoculum role

IRI: https://spec.industrialontologies.org/ontology/construct/InoculumRole

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:role

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › inoculum role

Definition

role held by a material entity containing biological material when it is being added, or is planned to be added, to initiate or establish biological growth, culture, infection, propagation or biological response

Explanatory Notes

In this context, biological material means material that includes cells, microorganisms, viruses, infected cells, viral seed material, or other biologically derived material used to initiate or establish a biological process.

Examples

• the inoculum role of a thawed CHO cell suspension added to fresh medium to initiate seed expansion; the inoculum role of an E. coli starter culture added to a fermenter to initiate microbial fermentation

Adapted From

• http://purl.obolibrary.org/obo/NCIT_C68774 and https://database.ich.org/sites/default/files/ICH_Q5A%28R2%29_Guideline_2023_1101.pdf

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

InoculumRole(x) → Role(x) ∧ ∃m (MaterialEntity(m) ∧ roleOf(x, m))

Semi-Formal Natural Language Axioms

if x is an ‘inoculum role’ then x is a ‘role’ that is the ‘role of’ some ‘material entity’

Description Logic

constr:InoculumRole ⊑ bfo:role

constr:InoculumRole ⊑ ∃ constr:roleOf .bfo:material_entity

SubClassOf: bfo:role

SubClassOf: constr:roleOf some bfo:material_entity