mycoplasma cell
IRI: https://spec.industrialontologies.org/ontology/construct/MycoplasmaCell
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: bacterium cell
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object › cell › bacterium cell › mycoplasma cell
Definition
bacterium cell that lacks a rigid cell wall and is capable of infecting mammalian cells
Explanatory Notes
Mycoplasma are wall-less bacteria with small genomes and minimal cellular architecture, which enables close association with mammalian cells and evasion of many routine microbiological detection approaches. In biopharmaceutical manufacturing, they are recognized as critical microbial contaminants of mammalian cell culture based processes. Their presence can alter cellular metabolism, affect gene expression, reduce viable cell density, and compromise product quality and safety. Because their size and lack of a rigid cell wall allow them to pass standard sterilizing filters and escape visual inspection, control strategies rely on validated multi-method detection workflows.
Examples
- Mycoplasma orale detected in a mammalian cell culture; Mycoplasma hyorhinis contamination in a CHO cell culture process; Mycoplasma arginini detected during cell substrate testing; mycoplasma contamination identified in a master cell bank; mycoplasma detected in an in-process cell culture sample
Adapted From
- https://www.sartorius.com/en/knowledge/science-snippets/what-is-mycoplasma-693938 and https://www.sciencedirect.com/science/article/abs/pii/S1045105610000783?via%3Dihub and https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/bit.27436
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
See the primitive rationale under bacterium
Formal Axioms
First-Order Logic Axioms
MycoplasmaCell(x) → BacteriumCell(x)
Semi-Formal Natural Language Axioms
if x is a ‘mycoplasma cell’ then x is a ‘bacterium cell’
Description Logic
SubClassOf: constr:BacteriumCell