N-glycosylated residue
IRI: https://spec.industrialontologies.org/ontology/construct/NGlycosylatedResidue
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: glycosylated residue
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › amino acid residue › modified amino acid residue › glycoconjugated residue › glycosylated residue › N-glycosylated residue
Direct subclasses:
Definition
glycosylated residue in which a carbohydrate or carbohydrate-derived group is attached to a nitrogen atom through formation of an N-glycosidic bond
Semi-Formal Definition:
every instance of ‘N-glycosylated residue’ is defined as exactly an instance of ‘glycosylated residue’ that ‘has proper continuant part at all times’ some ‘N-glycan moiety’
Explanatory Notes
This class includes amino acid residues, most commonly asparagine, that have a covalently attached carbohydrate group through an N-glycosidic linkage. In biopharmaceutical proteins, N-glycosylation is typically generated by enzymatic glycosylation pathways involving the endoplasmic reticulum and Golgi apparatus and yields N-linked glycans with characteristic core structures.
Examples
- N-glycosylated asparagine residue in the Fc region of a monoclonal antibody; Asparagine residue carrying an N-linked glycan in a recombinant glycoprotein; N-glycosylated asparagine residue within an N-X-S/T consensus sequon of a therapeutic protein
Adapted From
- http://purl.obolibrary.org/obo/MOD_00006
Formal Axioms
First-Order Logic Definition
NGlycosylatedResidue(x) ↔ GlycosylatedResidue(x) ∧ ∃y (hasProperContinuantPartAtAllTimes(x, y) ∧ NGlycanMoiety(y))
Description Logic
constr:NGlycosylatedResidue ≡ constr:GlycosylatedResidue ⊓ ∃ bfo:has_proper_continuant_part_at_all_times .constr:NGlycanMoiety
EquivalentTo: constr:GlycosylatedResidue and bfo:has_proper_continuant_part_at_all_times some constr:NGlycanMoiety
SubClassOf: constr:GlycosylatedResidue