axial point

IRI: https://spec.industrialontologies.org/ontology/construct/AxialPoint

Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/

SubClass Of: design point

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › design point › axial point

Definition

design point where one factor is set at an extreme high or low level and all other factors are set at their center levels

Explanatory Notes

Axial points, also called star points, occur in pairs for each factor and support estimation of quadratic effects and fitting of second-order response-surface models. Their distance from the design center is commonly denoted α.

Examples

• In a two-factor central composite design with factorial settings of pH 6.8 and 7.2 and temperature 35 °C and 37 °C, and center settings of pH 7.0 and temperature 36 °C, the design point specifying pH 6.6 and temperature 36 °C is an axial point; the design point specifying pH 7.4 and temperature 36 °C is its paired axial point.

Adapted From

• https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to define a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

AxialPoint(x) → DesignPoint(x)

Semi-Formal Natural Language Axioms

if x is an ‘axial point’ then x is a ‘design point’

Description Logic

constr:AxialPoint ⊑ constr:DesignPoint

SubClassOf: constr:DesignPoint