center point
IRI: https://spec.industrialontologies.org/ontology/construct/CenterPoint
Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/
SubClass Of: design point
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › design point › center point
Definition
design point where all factors are set at their middle levels
Explanatory Notes
Center points are commonly included in factorial and response-surface designs to assess overall curvature and, when replicated, to estimate pure error. A difference between the mean response at the center points and the mean response at the factorial points provides evidence that a first-order model may be inadequate. When replicated center-point runs are distributed through the run order, they may also reveal time-related changes in experimental performance.
Examples
- In a two-factor experiment where pH ranges from 6.8 to 7.2 and temperature from 35 °C to 37 °C, the design point specifying pH 7.0 and temperature 36 °C is a center point.
Adapted From
- https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
CenterPoint(x) → DesignPoint(x)
Semi-Formal Natural Language Axioms
if x is a ‘center point’ then x is a ‘design point’
Description Logic
SubClassOf: constr:DesignPoint