study design resolution

IRI: https://spec.industrialontologies.org/ontology/construct/StudyDesignResolution

Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/

SubClass Of: information content entity

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › study design resolution

Definition

information content entity that describes the degree to which a study design distinguishes different factor effects and interaction effects based on its confounding structure

Explanatory Notes

1) Study design resolution summarizes the aliasing structure of a regular fractional factorial design. Higher resolution indicates that lower-order effects are aliased only with higher-order effects, but usually requires more runs. 2) Resolution is commonly written as a Roman numeral. In a resolution III design, main effects are aliased with two-factor interactions. In a resolution IV design, main effects are not aliased with two-factor interactions, although two-factor interactions may be aliased with one another. In a resolution V design, no main effect or two-factor interaction is aliased with another main effect or two-factor interaction, although two-factor interactions may be aliased with three-factor interactions.

Examples

• Study design resolution with the value IV describes a fractional factorial design in which main effects can be estimated separately from two-factor interactions but not all two-factor interactions can be distinguished from each other.

Adapted From

• https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to define a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

StudyDesignResolution(x) → InformationContentEntity(x) ∧ ∃y (describes(x, y) ∧ StudyDesign(y))

Semi-Formal Natural Language Axioms

if x is a ‘study design resolution’ then x is an ‘information content entity’ and x ‘describes’ some ‘study design’

Description Logic

constr:StudyDesignResolution ⊑ constr:InformationContentEntity

constr:StudyDesignResolution ⊑ ∃ constr:describes .bfo:None

SubClassOf: constr:InformationContentEntity

SubClassOf: constr:describes some bfo:None