high mannose N-glycan moiety
IRI: https://spec.industrialontologies.org/ontology/construct/HighMannoseNGlycanMoiety
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: core pentasaccharide N-glycan moiety
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › N-glycan moiety › core pentasaccharide N-glycan moiety › high mannose N-glycan moiety
Definition
core pentasaccharide N-glycan moiety whose branches are extended only by mannose residues and whose total mannose count is commonly between five and nine
Examples
- Man5 N-glycan moiety detected on a monoclonal antibody Fc glycan; Man8 N-glycan moiety on a recombinant glycoprotein; High mannose N-glycan moiety observed as an elevated Man5 species during glycan profiling; Oligomannose N-glycan moiety containing terminal mannose residues without complex-type antenna extensions.
Adapted From
- https://www.sigmaaldrich.com/RS/en/technical-documents/technical-article/protein-biology/protein-labeling-and-modification/n-glycans
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of chemical bonds, structure and formation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
HighMannoseNGlycanMoiety(x) → CorePentasaccharideNGlycanMoiety(x)
Semi-Formal Natural Language Axioms
if x is a ‘high mannose N-glycan moiety’ then x is a ‘core pentasaccharide N-glycan moiety’