enzyme cofactor role
IRI: https://spec.industrialontologies.org/ontology/construct/EnzymeCofactorRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: molecular entity role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › enzyme cofactor role
Definition
role held by a molecular entity that is realized in an enzymatic reaction through enabling the catalytic activity of a particular enzyme
Examples
- Role held by magnesium ions stabilizing ATP in kinase reactions; Role held by zinc ions required for the catalytic activity of alcohol dehydrogenase; Role held by flavin adenine dinucleotide (FAD) acting as an electron carrier in redox enzymes; Role held by a heme group supporting oxidation reactions within cytochrome oxidase
Adapted From
- https://www.ebi.ac.uk/chebi/CHEBI:23357
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of molecular activity modulation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
EnzymeCofactorRole(x) → MolecularEntityRole(x)
Semi-Formal Natural Language Axioms
if x is an ‘enzyme cofactor role’ then x is a ‘molecular entity role’