continuous culture process operating mode

IRI: https://spec.industrialontologies.org/ontology/construct/ContinuousCultureProcessOperatingMode

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: continuous process operating mode

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › process characteristic › planned process operating mode › continuous process operating mode › continuous culture process operating mode

Direct subclasses:

• chemostat culture process operating mode
• perfusion culture process operating mode

Definition

continuous process operating mode of a culture process in which culture medium or other input material is introduced while culture material, spent medium, or product-containing harvest material is concomitantly removed over an operating interval

Examples

• continuous culture operating mode of a chemostat culture process, in which fresh medium is introduced while culture broth is concomitantly removed to maintain culture volume and regulate growth by dilution rate; continuous culture operating mode of a turbidostat culture process, in which medium is introduced while culture broth is concomitantly removed, with flow adjusted to maintain a target cell density or turbidity; continuous culture operating mode of a perfusion culture process, in which fresh medium is introduced while spent medium or product-containing harvest is concomitantly removed and cells are retained in the culture system

Adapted From

• https://www.cytivalifesciences.com/en/us/insights/what-are-the-different-types-of-bioreactors and https://infors-ht.com/en/blog/the-difference-between-batch-fed-batch-and-continuous-processes

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to define a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

ContinuousCultureProcessOperatingMode(x) → ContinuousProcessOperatingMode(x) ∧ ∃p (PlannedProcess(p) ∧ processCharacteristicOf(x, p) ∧ ∃c (CellCulture(c) ∧ hasParticipantAtSomeTime(p, c)))

Semi-Formal Natural Language Axioms

if x is a ‘continuous culture process operating mode’ then x is a ‘continuous process operating mode’ that is the ‘process characteristic of’ some ‘planned process’ that ‘has participant at some time’ some ‘cell culture’

Description Logic

constr:ContinuousCultureProcessOperatingMode ⊑ constr:ContinuousProcessOperatingMode

constr:ContinuousCultureProcessOperatingMode ⊑ ∃ constr:processCharacteristicOf .(constr:PlannedProcess ⊓ ∃ bfo:has_participant_at_some_time .constr:CellCulture)

SubClassOf: constr:ContinuousProcessOperatingMode

SubClassOf: constr:processCharacteristicOf some (constr:PlannedProcess and bfo:has_participant_at_some_time some constr:CellCulture)