O-glycosylated residue
IRI: https://spec.industrialontologies.org/ontology/construct/OGlycosylatedResidue
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: glycosylated residue
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › amino acid residue › modified amino acid residue › glycoconjugated residue › glycosylated residue › O-glycosylated residue
Definition
glycosylated residue in which a carbohydrate or carbohydrate-derived group is attached to an oxygen atom through formation of an O-glycosidic bond
Semi-Formal Definition:
every instance of ‘O-glycosylated residue’ is defined as exactly an instance of ‘glycosylated residue’ that ‘has proper continuant part at all times’ some ‘O-glycan moiety’
Explanatory Notes
This class includes amino acid residues, most commonly serine and threonine, that have a covalently attached carbohydrate group through an O-glycosidic linkage. O-glycosylation may occur on hydroxyl-containing residues and should be distinguished from N-glycosylation, where the glycan is attached through a nitrogen atom, and from glycation, where sugar attachment arises through non-enzymatic reaction with amino groups.
Examples
- O-glycosylated serine residue in a glycoprotein; O-glycosylated threonine residue in a mucin-like domain; Serine residue carrying an O-linked glycan in a recombinant therapeutic protein; Threonine residue carrying an O-linked glycan introduced through enzymatic glycosylation
Adapted From
- http://purl.obolibrary.org/obo/MOD_00396
Formal Axioms
First-Order Logic Definition
OGlycosylatedResidue(x) ↔ GlycosylatedResidue(x) ∧ ∃y (hasProperContinuantPartAtAllTimes(x, y) ∧ OGlycanMoiety(y))
Description Logic
constr:OGlycosylatedResidue ≡ constr:GlycosylatedResidue ⊓ ∃ bfo:has_proper_continuant_part_at_all_times .constr:OGlycanMoiety
EquivalentTo: constr:GlycosylatedResidue and bfo:has_proper_continuant_part_at_all_times some constr:OGlycanMoiety
SubClassOf: constr:GlycosylatedResidue