production culture growth phase

IRI: https://spec.industrialontologies.org/ontology/construct/ProductionCultureGrowthPhase

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: cell culture expansion process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › cell culture expansion process › production culture growth phase

Definition

cell culture expansion process that is a temporal part of a production culture process

Semi-Formal Definition:

every instance of ‘production culture growth phase’ is defined as exactly an instance of ‘cell culture expansion process’ that is ‘temporal part of’ some ‘production culture process’

Explanatory Notes

1) A production culture growth phase is an operational window within a production culture process, not the production culture process as a whole. It is distinguished from a production focused part of the same process because operating decisions and process monitoring are organized primarily around increase in cell number rather than target product accumulation. 2) The word “phase” here does not imply that this process is prescribed by an ISA88 phase

Examples

• growth window before a scheduled production-phase transition; increasing-cell-density window before induction or production-focused feeding begins; early fed-batch culture window managed primarily to increase viable cell density

Formal Axioms

First-Order Logic Definition

ProductionCultureGrowthPhase(x) ↔ CellCultureExpansionProcess(x) ∧ ∃s(ProductionCultureProcess(s) ∧ temporalPartOf(x, s))

Description Logic

constr:ProductionCultureGrowthPhase ≡ constr:CellCultureExpansionProcess ⊓ ∃ bfo:temporal_part_of .constr:ProductionCultureProcess

constr:ProductionCultureGrowthPhase ⊑ constr:CellCultureExpansionProcess

EquivalentTo: constr:CellCultureExpansionProcess and bfo:temporal_part_of some constr:ProductionCultureProcess

SubClassOf: constr:CellCultureExpansionProcess