enzyme activator role
IRI: https://spec.industrialontologies.org/ontology/construct/EnzymeActivatorRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: enzyme regulator role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › molecular activity regulator role › enzyme regulator role › enzyme activator role
Definition
role held by a molecular entity when it increases the catalytic activity of an enzyme without covalently modifying the enzyme
Examples
- Enzyme activator role held by magnesium ions that enhance the activity of DNA and RNA polymerases; Enzyme activator role held by chloride ions that activate salivary amylase; Enzyme activator role held by potassium ions that increase pyruvate kinase activity; Enzyme activator role held by calcium ions that promote protease and phospholipase activation
Adapted From
- https://www.ebi.ac.uk/chebi/CHEBI:195252
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of molecular activity modulation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
EnzymeActivatorRole(x) → EnzymeRegulatorRole(x)
Semi-Formal Natural Language Axioms
if x is an ‘enzyme activator role’ then x is an ‘enzyme regulator role’