miscibility

IRI: https://spec.industrialontologies.org/ontology/construct/Miscibility

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: capability

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:disposition › capability › miscibility

Definition

capability of two or more material entities to form a single homogeneous phase when combined as a mixture

Explanatory Notes

1) Miscibility concerns whether combined materials form one homogeneous phase rather than separating into multiple phases, such as liquid-liquid layering or solid-liquid phase separation. The term is used most often for liquids, but it can also be applied to gases and solid phases. 2) Whether a single phase forms and persists depends on properties of the combined materials, including chemical structure, composition, molar-mass distribution, molecular architecture, temperature, pressure, and mixing conditions.

Examples

• the miscibility of ethanol and water during buffer or formulation preparation; the miscibility of a cosolvent and aqueous formulation vehicle; the miscibility of two process solvents during solvent exchange; the miscibility of oxygen and nitrogen in a gas mixture; the limited miscibility of an oil phase and aqueous phase in an emulsion-forming process; the miscibility of polymer components in a solid dispersion

Adapted From

• https://www.sigmaaldrich.com/RS/en/technical-documents/technical-article/analytical-chemistry/purification/solvent-miscibility-table and https://goldbook.iupac.org/terms/view/MT07230

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

Miscibility(x) → Capability(x) ∧ ∃m1∃m2 (MaterialEntity(m1) ∧ MaterialEntity(m2) ∧ m1 ≠ m2 ∧ capabilityOf(x, m1) ∧ capabilityOf(x, m2))

Semi-Formal Natural Language Axioms

if x is a ‘miscibility’ then x is a ‘capability’ that is the ‘capability of’ at least two distinct ‘material entity’

Description Logic

constr:Miscibility ⊑ constr:Capability

constr:Miscibility ⊑ ∃ constr:capabilityOf .bfo:material_entity

SubClassOf: constr:Capability

SubClassOf: constr:capabilityOf some bfo:material_entity