response surface plot

IRI: https://spec.industrialontologies.org/ontology/construct/ResponseSurfacePlot

Defined In: https://spec.industrialontologies.org/ontology/biopharma/Statistics/

SubClass Of: bfo:IAO_0000308

Class Hierarchy

owl:Thing › bfo:IAO_0000308 › response surface plot

Definition

figure that depicts the predicted values of a dependent variable as a continuous surface over two or more independent variables

Explanatory Notes

A response surface plot is typically constructed from the predictions of a fitted regression model, most often a second-order (quadratic) polynomial, derived from data obtained in a designed experiment such as a central composite or Box–Behnken design. The figure illustrates how the predicted value of the dependent variable changes as the independent variables vary and may be presented as either a three-dimensional surface or a two-dimensional contour projection. Such plots facilitate the interpretation of main, interaction, and curvature effects and assist in locating regions of optimal or critical response.

Examples

three-dimensional surface showing predicted product titer across combinations of culture temperature and pH while feed rate is held fixed; contour plot showing predicted galactosylated-species abundance across coded manganese and zinc concentrations; response surface showing predicted chromatography yield as a function of load density and residence time at a fixed buffer pH

Adapted From

https://www.jmp.com/en/statistics-knowledge-portal/design-of-experiments/response-surface-methodology and https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

ResponseSurfacePlot(x) → Figure(x)

Semi-Formal Natural Language Axioms

if x is a ‘response surface plot’ then x is a ‘figure’

Description Logic

constr:ResponseSurfacePlot ⊑ bfo:None

SubClassOf: bfo:None