Changes in π’ Molecular Entity Ontology
- Maturity: π’ Released
New ontology in this release, review all classes: π’ Molecular Entity Ontology
Added
Classes
| Construct | Definition |
|---|---|
AcidBaseIndicatorRole | molecular color indicator role held by a molecular entity when it is used or planned to be used so that its color indicates the pH range of a material entity |
AcidicChargeVariantPopulation | protein charge variant population classified by a protein acidic charge variant classifier |
AminoAcid | organic molecular entity that contains a carboxyl group and one or more amino groups |
AminoAcidResidue | chemical moiety that is a proper part of a peptide or protein and that is the remaining portion of an amino acid resulting from peptide-bond formation |
AminoAcidSequence | biological sequence that is the ordered pattern of amino-acid residues that constitute a particular continuous peptide or protein molecule |
Anion | ion that is a monoatomic or polyatomic species having one or more elementary charges of the electron |
Antibody | protein that has the function to selectively bind some antigen |
AntimicrobialAgentRole | role held by a molecular entity when it is used or planned to be used to kill, inactivate, or inhibit the growth, proliferation, or replication of microorganisms or viruses |
AntioxidantRole | role held by a molecular entity when it is used or planned to be used to counteract oxidation or inhibit reactions initiated by dioxygen molecule, peroxides, or other oxidizing species |
BasicChargeVariantPopulation | protein charge variant population classified by a protein basic charge variant classifier |
BiantennaryComplexNGlycanMoiety | core pentasaccharide N-glycan moiety that has N-acetylglucosamine residues attached to both the Ξ±-3 and Ξ±-6 mannose branches and contains no mannose residues beyond those in the conserved core |
BiologicalSequence | generically dependent continuant that is the ordered pattern of residues that constitute a particular continuous DNA, RNA, peptide, or protein molecule |
BiologicalSequenceVariant | DNA or RNA or protein or peptide classified by a biological sequence variant classifier |
BiologicalSequenceVariantClassifier | classifier that classifies a DNA molecule, RNA molecule, peptide, or protein which has a biological sequence that differs from a specified reference biological sequence by one or more substitutions, insertions, deletions, truncations, or extensions |
Carbohydrate | organic molecular entity that is a polyhydroxy aldehyde, polyhydroxy ketone, derivative of such an entity, or condensation product of such entities |
Cation | ion that is a monoatomic or polyatomic species having one or more elementary charges of the proton |
ChargeVariantClassifier | classifier that classifies a population of material entities according to charge-related analytical properties relative to a reference material entity |
ChelatingAgentRole | role held by a molecular entity when it is used or planned to be used to bind a metal ion through two or more coordination sites |
ChemicalMoiety | material entity consisting of a linked collection of atoms or a single atom and that is a proper continuant part of a molecular entity |
ComplexAFucosylatedNGlycanMoiety | biantennary complex N-glycan moiety that has no fucose residues as parts |
ComplexAGalactosylatedNGlycanMoiety | biantennary complex N-glycan moiety that has no galactose residues as parts |
ComplexASialylatedNGlycanMoiety | biantennary complex N-glycan moiety that has no sialic acid residues as parts |
ComplexFucosylatedNGlycanMoiety | biantennary complex N-glycan moiety that has as part one or more fucose residues |
ComplexGalactosylatedNGlycanMoiety | biantennary complex N-glycan moiety that has as part one or more galactose residues |
ComplexNGlycolylneuraminicAcidContainingNGlycanMoiety | complex sialylated N-glycan moiety that has as part one or more N-glycolylneuraminic acid (NGNA) residues |
ComplexSialylatedNGlycanMoiety | biantennary complex N-glycan moiety that has as part one or more sialic acid residues |
CorePentasaccharideNGlycanMoiety | N-glycan moiety that contains the core pentasaccharide ManβGlcNAcβ, consisting of a di-N-acetyl-chitobiose unit extended by a branched mannose trisaccharide |
DeamidatedResidue | modified amino acid residue in which a carboxamide group has been converted to a carboxyl group, involving a net gain of oxygen and loss of nitrogen and hydrogen |
DeoxyribonucleicAcid | nucleic acid that is composed of nucleotides containing deoxyribose |
DioxygenMolecule | inorganic molecular entity consisting of two oxygen atoms covalently bonded to each other |
Endotoxin | lipopolysaccharide with an endotoxin role |
EndotoxinRole | molecular toxin role held by a lipopolysaccharide (LPS) that originates from Gram-negative bacterial cellular material |
EnzymeActivatorRole | role held by a molecular entity when it increases the catalytic activity of an enzyme without covalently modifying the enzyme |
EnzymeCofactorRole | role held by a molecular entity that is realized in an enzymatic reaction through enabling the catalytic activity of a particular enzyme |
EnzymeInhibitorRole | role held by a molecular entity that is realized in an enzyme catalyzed reaction through decreasing or preventing the catalytic activity of the enzyme |
EnzymeRegulatorRole | role held by a molecular entity when it binds to an enzyme and modulates its catalytic activity |
FucoseResidue | monosaccharide residue that is the remaining portion of fucose after formation of a glycosidic bond |
GalactoseResidue | monosaccharide residue that is the remaining portion of galactose after formation of a glycosidic bond |
GlycatedResidue | glycoconjugated residue that is formed by non-enzymatic covalent attachment of a reducing sugar to an amino group of an amino acid residue, producing a Schiff-base or Amadori-type ketosamine adduct |
GlycoconjugatedResidue | modified amino acid residue that has a covalently attached carbohydrate or carbohydrate-derived group, formed either through enzymatic glycosidic bond formation or through non-enzymatic glycation involving a Schiff-base or Amadori-type ketosamine adduct |
Glycoprotein | protein that includes at least one glycosylated residue |
GlycosylatedResidue | glycoconjugated residue that results from replacement of a hydrogen atom with a carbohydrate-like group through formation of a glycosidic bond |
GrowthFactor | protein or peptide with a growth factor role |
GrowthFactorRole | role held by a peptide or protein that is realized in receptor-mediated signaling processes that stimulate cellular growth, proliferation, survival, or differentiation |
HeterodimericAntibody | antibody consisting of two heavy chains and two light chains in which the two heavy chains differ in amino acid sequence, the two light chains differ in amino acid sequence, or both |
HighMannoseNGlycanMoiety | core pentasaccharide N-glycan moiety whose branches are extended only by mannose residues and whose total mannose count is commonly between five and nine |
HomodimericAntibody | antibody consisting of two heavy chains and two light chains in which the two heavy chains have the same amino acid sequence and the two light chains have the same amino acid sequence |
Hormone | organic molecular entity with a hormone role |
HormoneRole | role held by an organic molecular entity that is realized in receptor-mediated signaling or regulatory processes that modulate the activity, metabolism, growth, or differentiation of cells or tissues |
HybridNGlycanMoiety | core pentasaccharide N-glycan moiety that contains both unsubstituted terminal mannose residues and at least one mannose residue substituted by an N-acetylglucosamine unit |
InorganicMolecularEntity | molecular entity that contains no carbon |
Ion | molecular entity having a net electric charge |
Lipid | organic molecular entity belonging to a structurally diverse class of hydrophobic or amphipathic entities that includes fats, oils, waxes, phospholipids, steroids, and related entities |
LipidPrecursorRole | role of a molecular entity that provides carbon or functional groups required for the biosynthetic formation of complex lipids such as fatty acids, phospholipids, or sterols |
Lipopolysaccharide | organic molecular entity that consists of lipid A covalently linked to a core oligosaccharide and, where present, an O-antigen polysaccharide |
MainChargeVariantPopulation | protein charge variant population classified by a protein main charge variant classifier |
MannoseResidue | monosaccharide residue that is the remaining portion of mannose after formation of a glycosidic bond |
ModifiedAminoAcidResidue | amino acid residue that has undergone covalent modification of side-chain or backbone atoms while remaining part of an intact peptide or protein |
MolecularActivityRegulatorRole | role held by a molecular entity when it modulates the activity of another molecular entity |
MolecularColorIndicatorRole | molecular visual indicator role held by a molecular entity when it is used or planned to be used so that a change in its color indicates the presence, amount, or condition of a particular material entity or quality |
MolecularEntity | material entity that is a constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, or other chemically distinguishable entity |
MolecularEntityPopulation | object aggregate that has one or more molecular entities as member parts and has only molecular entities as member parts |
MolecularEntityRole | role of a molecular entity that reflects a chemical or biochemical behavior it may exhibit under specified conditions |
MolecularIndicatorRole | role held by a molecular entity when it is used or planned to be used so that an observable change in that molecular entity indicates the presence, amount, or condition of a particular material entity or quality |
MolecularMessengerRole | role held by a molecular entity that participates in transmitting biological signals between or within cells, tissues, or organs to support coordination of biological processes |
MolecularToxin | molecular entity with a molecular toxin role |
MolecularToxinRole | molecular entity role held by a molecular entity in a biological exposure setting in which its chemical or biochemical activity is treated as capable of causing damage or dysfunction to a cell or organism |
MolecularVisualIndicatorRole | molecular indicator role held by a molecular entity when it is used or planned to be used so that a visible change in that molecular entity indicates the presence, amount, or condition of a particular material entity or quality |
Monosaccharide | carbohydrate that consists of a single polyhydroxy aldehyde or polyhydroxy ketone unit with three or more carbon atoms and is not glycosidically linked to another carbohydrate unit |
MonosaccharideResidue | chemical moiety that is a proper part of an oligosaccharide, polysaccharide, or glycoconjugate and that is the remaining portion of a monosaccharide after formation of a glycosidic bond |
N4GlycosylLAsparagine | N-glycosylated residue in which a glycan is covalently attached to the side-chain nitrogen of an L-asparagine residue |
NGlycanMoiety | chemical moiety that is the remaining portion of a glycan resulting from its covalent attachment to the side-chain nitrogen of an asparagine or arginine residue |
NGlycolylneuraminicAcidResidue | sialic acid residue that is the remaining portion of N-glycolylneuraminic acid after formation of a glycosidic bond |
NGlycosylatedResidue | glycosylated residue in which a carbohydrate or carbohydrate-derived group is attached to a nitrogen atom through formation of an N-glycosidic bond |
NonProteinogenicAminoAcid | amino acid that is not normally incorporated into polypeptide chains by ribosomal translation |
NucleicAcid | organic molecular entity composed of two or more nucleotides linked by phosphodiester bonds |
Nucleoside | organic molecular entity that consists of a nucleobase linked through a nitrogen atom to a sugar such as ribose or deoxyribose |
Nucleotide | organic molecular entity that consists of a nucleoside having one or more phosphate groups attached to its sugar moiety |
NucleotideSequence | biological sequence that is the ordered pattern of nucleotide residues that constitute a particular continuous DNA or RNA molecule |
OGlycanMoiety | chemical moiety that is the remaining portion of a glycan resulting from its covalent attachment to the side-chain hydroxyl oxygen of a serine, threonine, hydroxylysine, or hydroxyproline residue |
OGlycosylatedResidue | glycosylated residue in which a carbohydrate or carbohydrate-derived group is attached to an oxygen atom through formation of an O-glycosidic bond |
OrganicMolecularEntity | molecular entity that contains carbon |
OxidizedResidue | modified amino acid residue that results from covalent changes involving loss of hydrogen atoms or addition of oxygen atoms to the residue |
Peptide | organic molecular entity consisting of two or more amino acid residues linked by peptide bonds |
Polyamine | organic molecular entity that contains two or more amino groups |
Polypeptide | peptide containing ten or more amino acid residues |
Polysaccharide | carbohydrate consisting of large numbers of monosaccharide residues linked glycosidically |
Protein | organic molecular entity that consists of one or more polypeptide chains of sufficient length or molecular mass to be distinguished from peptides |
ProteinAcidicChargeVariantClassifier | protein charge variant classifier that classifies a molecular entity population composed of proteins or protein fragments as differing from a reference protein form by having a lower isoelectric point or lower net electric charge under the relevant analytical conditions |
ProteinAggregate | organic molecular entity that consists of two or more protein molecules or protein fragments associated through non-covalent interactions, covalent bonds other than peptide bonds, or both |
ProteinBasicChargeVariantClassifier | protein charge variant classifier that classifies a molecular entity population composed of proteins or protein fragments as differing from a reference protein form by having a higher isoelectric point or higher net electric charge under the relevant analytical conditions |
ProteinChargeVariantClassifier | charge variant classifier that classifies a molecular entity population composed of proteins or protein fragments according to charge-related analytical behavior relative to a reference protein form |
ProteinChargeVariantPopulation | molecular entity population classified by a protein charge variant classifier |
ProteinFragment | peptide or protein that was a proper part of a protein molecule and resulted from cleavage of one or more peptide bonds within that protein |
ProteinHighMolecularWeightPopulation | protein size variant population classified by a protein high molecular weight variant classifier |
ProteinHighMolecularWeightVariantClassifier | protein size variant classifier that classifies a molecular entity population composed of proteins or protein aggregates as having greater molecular size or molecular weight than a reference protein form |
ProteinLowMolecularWeightPopulation | protein size variant population classified by a protein low molecular weight variant classifier |
ProteinLowMolecularWeightVariantClassifier | protein size variant classifier that classifies a molecular entity population composed of proteins or protein fragments as having lower molecular size or molecular weight than a reference protein form |
ProteinMainChargeVariantClassifier | protein charge variant classifier that classifies a molecular entity population composed of proteins or protein fragments as having charge-related analytical behavior comparable to the reference protein form under the relevant analytical conditions |
ProteinSizeVariantClassifier | size variant classifier that classifies a molecular entity population composed of proteins, protein fragments, or protein aggregates according to molecular size or molecular weight relative to a reference protein form |
ProteinSizeVariantPopulation | molecular entity population classified by a protein size variant classifier |
ProteinogenicAminoAcid | amino acid that is normally incorporated into polypeptide chains by ribosomal translation |
RibonucleicAcid | nucleic acid that is composed of nucleotide units containing ribose |
Ribonucleoside | nucleoside where the sugar component is D-ribose |
Salt | molecular entity that is an assembly of cations and anions |
SialicAcidResidue | monosaccharide residue that is the remaining portion of sialic acid after formation of a glycosidic bond |
SizeVariantClassifier | classifier that classifies a population of material entities according to size-related analytical properties relative to a reference material entity |
Steroid | lipid that has a core structure of four fused carbon rings, consisting of three six-membered rings and one five-membered ring |
TraceElementRole | role held by a molecular entity composed of a single chemical element that originates from a source external to cells, is present in a small amount, and supports biological processes in those cells |
Vitamin | organic molecular entity with a vitamin role |
VitaminRole | role held by an organic molecular entity that is used in small amounts to support metabolic or physiological functions and whose adequate availability depends on external supply or environmental activation |
WaterMolecule | inorganic molecular entity consisting of an oxygen atom that is covalently bonded to two hydrogen atoms |